Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata


Acacia dealbata biomass, either from forest exploitation or from the management of invasive species, can be a strategic topic, namely as a source of high-value compounds. In this sense, the present study aimed at the detailed characterization of the lipophilic components of different morphological parts of A. dealbata and the evaluation of their cytotoxicity in cells representative of different mammals' tissues. The chemical composition of lipophilic extracts from A. dealbata bark, wood and leaves was evaluated using gas chromatography-mass spectrometry (GC-MS). Terpenic compounds (representing 50.2%-68.4% of the total bark and leaves extracts, respectively) and sterols (60.5% of the total wood extract) were the main components of these extracts. Other constituents, such as fatty acids, long-chain aliphatic alcohols, monoglycerides, and aromatic compounds were also detected in the studied extracts. All the extracts showed low or no cytotoxicity in the different cells tested, demonstrating their safety profile and highlighting their potential to be used in nutraceutical or pharmaceutical applications. This study is therefore an important contribution to the valorization of A. dealbata, demonstrating the potential of this species as a source of high value lipophilic compounds.




Biochemistry & Molecular Biology; Chemistry


Oliveira, CSD; Moreira, P; Resende, J; Cruz, MT; Pereira, CMF; Silva, AMS; Santos, SAO; Silvestre, AJD

nossos autores


This work was carried out under the Project inpactus-innovative products and technologies from eucalyptus, Project No. 21874 funded by Portugal 2020 through European Regional Development Fund (ERDF) in the frame of COMPETE 2020 no 246/AXIS II/2017. The authors thank FCT/MEC for the financial support to CICECO-Aveiro Institute of Materials (UIDB/50011/2020 & UIDP/50011/2020), LAQV-REQUIMTE (UIDB/50006/2020), and CNC.IBILI Consortia (UIDB/04539/2020), and when appropriate the co-financing support by FEDER, under the PT2020 Partnership Agreement. Sonia A. O. Santos and Judite Resende thank the project AgroForWealth: Biorefining of agricultural and forest by-products and wastes: integrated strategic for valorization of resources towards society wealth and sustainability (CENTRO-01-0145-FEDER-000001), for the contract and research grant, respectively.

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