authors |
Calhau, IB; Gomes, AC; Bruno, SM; Coelho, AC; Magalhaes, CIR; Romao, CC; Valente, AA; Goncalves, IS; Pillinger, M |
nationality |
International |
journal |
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY |
author keywords |
Molybdenum; Carbon monoxide; Isocyanide ligands; Drug delivery; Layered compounds |
keywords |
CARBON-MONOXIDE; NANOPARTICLES; DELIVERY; COMPLEX; OXIDE; EXCHANGE; CARRIERS; DESIGN |
abstract |
The photoactivatable CO-releasing molecule (photoCORM) [Mo(CO)(3)(CNCH2COOH)(3)] (ALF795) has been incorporated into a Zn,Al layered double hydroxide (LDH) host by a coprecipitation synthesis strategy. Powder X-ray diffraction (PXRD) of the resultant material Zn,Al-ALF795 showed that the ALF795 guest molecules assembled into a monolayer to give a basal spacing of 16.0 angstrom. FTIR and(13)C{H-1} CP MAS NMR spectroscopy confirmed that the molecular structure of the tricarbonyl complex was retained upon intercalation. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and elemental analyses confirmed the phase-purity of Zn,Al-ALF795. The myoglobin assay was used to demonstrate that intercalated ALF795 retains the photoactive behavior of the free CORM, with a substantial fraction (42 %) of the high CO payload (2.46 mmol g(-1)) being released after exposure to UV light for 3 h under simulated physiological conditions. In addition, gas chromatography was used to track sequential light- and H2O2-triggered decarbonylation of free and intercalated ALF795. In biological buffer solution (HEPES), less than 2 % Mo leaching from Zn,Al-ALF795 took place after 5 h, showing the strong capacity of the LDH host to retain the unaltered complex and decarbonylation fragments. |
publisher |
WILEY-V C H VERLAG GMBH |
issn |
1434-1948 |
isbn |
1099-0682 |
year published |
2020 |
volume |
2020 |
issue |
28 |
beginning page |
2726 |
ending page |
2736 |
digital object identifier (doi) |
10.1002/ejic.202000202 |
web of science category |
Chemistry, Inorganic & Nuclear |
subject category |
Chemistry |
unique article identifier |
WOS:000548603500001
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
2.529 |
5 year journal impact factor |
2.284 |
category normalized journal impact factor percentile |
65.556 |
dimensions (citation analysis):
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altmetrics (social interaction):
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