authors |
Amaral, AJR; Gaspar, VM; Mano, JF |
nationality |
International |
journal |
POLYMER JOURNAL |
keywords |
POLYMERS; OXIDATION |
abstract |
The precise chemical modification of marine-derived biopolymers provides a unique opportunity for fabricating a toolbox of bioactive (bio)materials with modulated physicochemical and biological properties. Herein, the beta-glucan laminarin was functionalized with phenylboronic acid (PBA) moieties that impart chemical reactivity toward diol-containing polymers via boronate esterification. The modification, which involved a two-pot reaction, was successfully confirmed by nuclear magnetic resonance spectroscopy. The resultant biopolymer readily established boronate ester-crosslinked hydrogels with poly(vinyl alcohol) (PVA) within seconds under physiological conditions. These hydrogels exhibited improved rheological properties, which were easily tunable, and revealed a rapid self-healing behavior upon rupture. Moreover, boronate ester bonds enabled the fabrication of reactive oxygen species-responsive and shear-thinning gels that can be administered in situ and respond to the oxidation state of the surrounding microenvironment. Importantly, due to the catalyst-free and mild-crosslinking conditions, the generated laminarin-PBA/PVA hydrogels did not show toxicity upon direct contact with preosteoblasts for up to 48 h, and thus constitute a promising platform for tissue engineering and drug delivery applications. |
publisher |
NATURE PUBLISHING GROUP |
issn |
0032-3896 |
isbn |
1349-0540 |
year published |
2020 |
volume |
52 |
issue |
8 |
beginning page |
997 |
ending page |
1006 |
digital object identifier (doi) |
10.1038/s41428-020-0348-3 |
web of science category |
Polymer Science |
subject category |
Polymer Science |
unique article identifier |
WOS:000529488600001
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
2.826 |
5 year journal impact factor |
2.247 |
category normalized journal impact factor percentile |
70.225 |
dimensions (citation analysis):
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altmetrics (social interaction):
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