|
authors |
Pedro, SN; Freire, CSR; Silvestre, AJD; Freire, MG |
|
nationality |
International |
|
journal |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
|
author keywords |
active pharmaceutical ingredients; drug delivery systems; formulations; ionic liquids; solubility; permeability |
|
keywords |
WATER-SOLUBLE DRUGS; TRANSDERMAL DELIVERY; AQUEOUS-SOLUTIONS; SKIN PERMEATION; 1-METHYL-3-OCTYLIMIDAZOLIUM CHLORIDE; POLYMORPHIC TRANSFORMATION; CRYSTALLIZATION CONTROL; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT PROPERTIES; POTENTIAL CARRIERS |
|
abstract |
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems. |
|
publisher |
MDPI |
|
isbn |
1422-0067 |
|
year published |
2020 |
|
volume |
21 |
|
issue |
21 |
|
digital object identifier (doi) |
10.3390/ijms21218298 |
|
web of science category |
Biochemistry & Molecular Biology; Chemistry, Multidisciplinary |
|
subject category |
Biochemistry & Molecular Biology; Chemistry |
|
unique article identifier |
WOS:000588911000001
|
