The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications
authors Pedro, SN; Freire, CSR; Silvestre, AJD; Freire, MG
nationality International
journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
author keywords active pharmaceutical ingredients; drug delivery systems; formulations; ionic liquids; solubility; permeability
keywords WATER-SOLUBLE DRUGS; TRANSDERMAL DELIVERY; AQUEOUS-SOLUTIONS; SKIN PERMEATION; 1-METHYL-3-OCTYLIMIDAZOLIUM CHLORIDE; POLYMORPHIC TRANSFORMATION; CRYSTALLIZATION CONTROL; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT PROPERTIES; POTENTIAL CARRIERS
abstract Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.
publisher MDPI
isbn 1422-0067
year published 2020
volume 21
issue 21
digital object identifier (doi) 10.3390/ijms21218298
web of science category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000588911000001
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 4.556
5 year journal impact factor 4.653
category normalized journal impact factor percentile 74.208
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