resumo
The complex tissue-specific physiology that is orchestrated from the nano- to the macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying biological processes, has inspired the design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli-responsive features. Recently, hydrogels and nanoparticles have been combined in advanced nanocomposite hybrid platforms expanding their range of biomedical applications. The ease and flexibility of attaining modular nanocomposite hydrogel constructs by selecting different classes of nanomaterials/hydrogels, or tuning nanoparticle-hydrogel physicochemical interactions widely expands the range of attainable properties to levels beyond those of traditional platforms. This review showcases the intrinsic ability of hybrid constructs to react to external or internal/physiological stimuli in the scope of developing sophisticated and intelligent systems with application-oriented features. Moreover, nanoparticle-hydrogel platforms are overviewed in the context of encoding stimuli-responsive cascades that recapitulate signaling interplays present in native biosystems. Collectively, recent breakthroughs in the design of stimuli-responsive nanocomposite hydrogels improve their potential for operating as advanced systems in different biomedical applications that benefit from tailored single or multi-responsiveness.
palavras-chave
DRUG-DELIVERY; HYALURONIC-ACID; CONTROLLED-RELEASE; SUPRAMOLECULAR HYDROGEL; NANOPARTICLE-HYDROGEL; INJECTABLE HYDROGEL; MICRONEEDLE PATCH; TRIGGERED RELEASE; HYBRID HYDROGELS; POLYMERS
categoria
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
autores
Lavrador, P; Esteves, MR; Gaspar, VM; Mano, JF
nossos autores
agradecimentos
P.L. acknowledges an individual PhD fellowship from the Portuguese Foundation for Science and Technology (SFRH/BD/141834/2018). This work was supported by the Programa Operacional Competitividade e InternacionalizacAo (POCI), in the component FEDER, and by national funds (OE) through FCT/MCTES, in the scope of the projects Margel (PTDC/BTM-MAT/31498/2017) and PANGEIA (PTDC/BTM-SAL/30503/2017). The PANGEIA project is also acknowledged for the junior researcher contract of Vitor Gaspar. This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 and UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES.