Stimuli-Responsive Nanocomposite Hydrogels for Biomedical Applications
authors Lavrador, P; Esteves, MR; Gaspar, VM; Mano, JF
nationality International
journal ADVANCED FUNCTIONAL MATERIALS
author keywords biomaterials; nanoparticle‐ hydrogel hybrids; self‐ regulated materials; stimuli‐ responsive materials; tissue engineering
keywords DRUG-DELIVERY; HYALURONIC-ACID; CONTROLLED-RELEASE; SUPRAMOLECULAR HYDROGEL; NANOPARTICLE-HYDROGEL; INJECTABLE HYDROGEL; MICRONEEDLE PATCH; TRIGGERED RELEASE; HYBRID HYDROGELS; POLYMERS
abstract The complex tissue-specific physiology that is orchestrated from the nano- to the macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying biological processes, has inspired the design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli-responsive features. Recently, hydrogels and nanoparticles have been combined in advanced nanocomposite hybrid platforms expanding their range of biomedical applications. The ease and flexibility of attaining modular nanocomposite hydrogel constructs by selecting different classes of nanomaterials/hydrogels, or tuning nanoparticle-hydrogel physicochemical interactions widely expands the range of attainable properties to levels beyond those of traditional platforms. This review showcases the intrinsic ability of hybrid constructs to react to external or internal/physiological stimuli in the scope of developing sophisticated and intelligent systems with application-oriented features. Moreover, nanoparticle-hydrogel platforms are overviewed in the context of encoding stimuli-responsive cascades that recapitulate signaling interplays present in native biosystems. Collectively, recent breakthroughs in the design of stimuli-responsive nanocomposite hydrogels improve their potential for operating as advanced systems in different biomedical applications that benefit from tailored single or multi-responsiveness.
publisher WILEY-V C H VERLAG GMBH
issn 1616-301X
isbn 1616-3028
year published 2021
volume 31
issue 8
digital object identifier (doi) 10.1002/adfm.202005941
web of science category 30
subject category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
unique article identifier WOS:000590069100001
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journal analysis (jcr 2019):
journal impact factor 16.836
5 year journal impact factor 15.722
category normalized journal impact factor percentile 95.322
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