authors |
Lin, Z; Pinto, RV; Henriques, C; Antunes, F; Pires, J; Pinto, ML; Rocha, J |
nationality |
International |
journal |
MICROPOROUS AND MESOPOROUS MATERIALS |
author keywords |
Nitric oxide; Porous materials; Titanosilicates; Copper; Therapeutic applications |
keywords |
SLOW-RELEASE; ETS-4; STORAGE; NO |
abstract |
Copper was incorporated into microporous titanosilicate ETS-4 framework via the in situ hydrothermal synthesis to achieve a more controlled and extended nitric oxide (NO) release profile. Exogeneous delivery of this gasotransmitter may be effective in the therapeutic setting and titanosilicates, in particular ETS-4, has already evidenced its potential as a NO carrier. Copper ions have high affinity for NO coordination and their substitution within the ETS-4 framework was confirmed by energy dispersive X-ray spectrometry (EDS). Samples were also characterized by PXRD, SEM microscopy, UV-Vis and Raman spectroscopy, TG and DSC. ETS-4Cu presents higher NO adsorption capacity (up to 4.5 mmol g-1 solid) comparing with the parent material, excellent stability in biological media and exhibits high compatibility in different cell lines, including primary keratinocytes (HEKn). Its NO release profile in biological conditions demonstrated a controlled release over at least 4 h, never achieved by any other porous materials so far. This may be reflected by its peculiar NO adsorption mechanism through the formation of stable nitro species on the framework. |
publisher |
ELSEVIER |
issn |
1387-1811 |
isbn |
1873-3093 |
year published |
2021 |
volume |
322 |
digital object identifier (doi) |
10.1016/j.micromeso.2021.111154 |
web of science category |
9 |
subject category |
Chemistry, Applied; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary |
unique article identifier |
WOS:000660462500001
|