Improved therapeutic nitric oxide delivery by microporous Cu-bearing titanosilicate

authors	Lin, Z; Pinto, RV; Henriques, C; Antunes, F; Pires, J; Pinto, ML; Rocha, J
nationality	International
journal	MICROPOROUS AND MESOPOROUS MATERIALS
author keywords	Nitric oxide; Porous materials; Titanosilicates; Copper; Therapeutic applications
keywords	SLOW-RELEASE; ETS-4; STORAGE; NO
abstract	Copper was incorporated into microporous titanosilicate ETS-4 framework via the in situ hydrothermal synthesis to achieve a more controlled and extended nitric oxide (NO) release profile. Exogeneous delivery of this gasotransmitter may be effective in the therapeutic setting and titanosilicates, in particular ETS-4, has already evidenced its potential as a NO carrier. Copper ions have high affinity for NO coordination and their substitution within the ETS-4 framework was confirmed by energy dispersive X-ray spectrometry (EDS). Samples were also characterized by PXRD, SEM microscopy, UV-Vis and Raman spectroscopy, TG and DSC. ETS-4Cu presents higher NO adsorption capacity (up to 4.5 mmol g-1 solid) comparing with the parent material, excellent stability in biological media and exhibits high compatibility in different cell lines, including primary keratinocytes (HEKn). Its NO release profile in biological conditions demonstrated a controlled release over at least 4 h, never achieved by any other porous materials so far. This may be reflected by its peculiar NO adsorption mechanism through the formation of stable nitro species on the framework.
publisher	ELSEVIER
issn	1387-1811
isbn	1873-3093
year published	2021
volume	322
digital object identifier (doi)	10.1016/j.micromeso.2021.111154
web of science category	9
subject category	Chemistry, Applied; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
unique article identifier	WOS:000660462500001