Improved therapeutic nitric oxide delivery by microporous Cu-bearing titanosilicate

resumo

Copper was incorporated into microporous titanosilicate ETS-4 framework via the in situ hydrothermal synthesis to achieve a more controlled and extended nitric oxide (NO) release profile. Exogeneous delivery of this gasotransmitter may be effective in the therapeutic setting and titanosilicates, in particular ETS-4, has already evidenced its potential as a NO carrier. Copper ions have high affinity for NO coordination and their substitution within the ETS-4 framework was confirmed by energy dispersive X-ray spectrometry (EDS). Samples were also characterized by PXRD, SEM microscopy, UV-Vis and Raman spectroscopy, TG and DSC. ETS-4Cu presents higher NO adsorption capacity (up to 4.5 mmol g-1 solid) comparing with the parent material, excellent stability in biological media and exhibits high compatibility in different cell lines, including primary keratinocytes (HEKn). Its NO release profile in biological conditions demonstrated a controlled release over at least 4 h, never achieved by any other porous materials so far. This may be reflected by its peculiar NO adsorption mechanism through the formation of stable nitro species on the framework.

palavras-chave

SLOW-RELEASE; ETS-4; STORAGE; NO

categoria

Chemistry, Applied; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary

autores

Lin, Z; Pinto, RV; Henriques, C; Antunes, F; Pires, J; Pinto, ML; Rocha, J

nossos autores

agradecimentos

This research was financed by Fundacao para a Ciencia e a Tecnologia (FCT) through projects PTDC/MEDQUI/28721/2017 and developed in the scope of the projects UIDB/00100/2020 (CQE), UIDB/04028/2020 & UIDP/04028/2020 (CERENA), and CICECO-Aveiro Institute of Material (UIDB/50011/2020 & UIDP/50011/2020) financed by Portuguese funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement. RVP acknowledges for the grant 16/BAD/2017 provided by Colegio de Quimica, University of Lisbon.

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