Pesticides and Male Fertility: A Dangerous Crosstalk
authors Moreira, S; Pereira, SC; Seco-Rovira, V; Oliveira, PF; Alves, MG; Pereira, MD
nationality International
journal METABOLITES
author keywords male infertility; pesticides; EDCs; obesogens; Leydig cells; Sertoli cells; peritubular myoid cells; spermatogenesis; testicular metabolism; pesticides detection; metabolic changes detection
keywords NON-TARGETED DETECTION; TESTICULAR TOXICITY; MALE-INFERTILITY; PPAR-ALPHA; EXPOSURE; RECEPTOR; CELLS; METABOLISM; MODE; CARBENDAZIM
abstract In recent decades, an increasing incidence of male infertility has been reported. Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these chemicals, suggesting they are contributors for the development of human infertility. Data from literature highlight the ability of certain pesticides and/or their metabolites to persist in the environment for long periods of time, as well as to bioaccumulate in the food chain, thus contributing for their chronic exposure. Furthermore, pesticides can act as endocrine disrupting chemicals (EDCs), interfering with the normal function of natural hormones (which are responsible for the regulation of the reproductive system), or even as obesogens, promoting obesity and associated comorbidities, like infertility. Several in vitro and in vivo studies have focused on the effects and possible mechanisms of action of these pesticides on the male reproductive system that cause sundry negative effects, even though through diverse mechanisms, but all may lead to infertility. In this review, we present an up-to-date overview and discussion of the effects, and the metabolic and molecular features of pesticides on somatic cells and germinal tissues that affect germ cell differentiation.
publisher MDPI
isbn 2218-1989
year published 2021
volume 11
issue 12
digital object identifier (doi) 10.3390/metabo11120799
web of science category 15
subject category Biochemistry & Molecular Biology
unique article identifier WOS:000735955200001
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journal analysis (jcr 2019):
journal impact factor 4.097
5 year journal impact factor Not Available
category normalized journal impact factor percentile 68.182
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