Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus
authors Paul, AK; Paul, A; Jahan, R; Jannat, K; Bondhon, TA; Hasan, A; Nissapatorn, V; Pereira, ML; Wilairatana, P; Rahmatullah, M
nationality International
journal MICROORGANISMS
author keywords rheumatoid arthritis; probiotics; Lactobacillus; Prevotella; gut microbiota
keywords LAYER PROTEIN-A; GUT MICROBIOTA; DOUBLE-BLIND; MATRIX METALLOPROTEINASES; PREVOTELLA-INTERMEDIA; VITAMIN-B-6 STATUS; OXIDATIVE STRESS; DISEASE-ACTIVITY; BACTERIAL-DNA; SUPPLEMENTATION
abstract Rheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, Prevotella, and imbalance in the gastrointestinal microbiota are possible sources of the initiation or progression of rheumatoid arthritis, although the detailed mechanisms still need to be elucidated. Probiotics containing Lactobacillus spp. are commonly used as alleviating agents or food supplements to manage diarrhea, dysentery, develop immunity, and maintain general health. The mechanism of action of Lactobacillus spp. against rheumatoid arthritis is still not clearly known to date. In this narrative review, we recapitulate the findings of recent studies to understand the overall pathogenesis of rheumatoid arthritis and the roles of probiotics, particularly L. casei or L. acidophilus, in the management of rheumatoid arthritis in clinical and preclinical studies.
publisher MDPI
isbn 2076-2607
year published 2021
volume 9
issue 5
digital object identifier (doi) 10.3390/microorganisms9051070
web of science category 17
subject category Microbiology
unique article identifier WOS:000662401700001
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 4.152
5 year journal impact factor Not Available
category normalized journal impact factor percentile 72.963
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