Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts
authors Neto, CMS; Lima, FC; Morais, RP; de Andrade, LRM; de Lima, R; Chaud, MV; Pereira, MM; Junior, RLCD; Cardoso, JC; Zielinska, A; Souto, EB; Lima, AS; Severino, P
nationality International
journal TOXICS
author keywords multi-walled carbon nanotubes; rutin; flavonoids; drug delivery; cytotoxicity
abstract Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose-effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.
publisher MDPI
isbn 2305-6304
year published 2021
volume 9
issue 8
digital object identifier (doi) 10.3390/toxics9080173
web of science category 10
subject category Environmental Sciences; Toxicology
unique article identifier WOS:000690137400001
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journal impact factor 3.271
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category normalized journal impact factor percentile 65.616
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