Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts

authors	Neto, CMS; Lima, FC; Morais, RP; de Andrade, LRM; de Lima, R; Chaud, MV; Pereira, MM; Junior, RLCD; Cardoso, JC; Zielinska, A; Souto, EB; Lima, AS; Severino, P
nationality	International
journal	TOXICS
author keywords	multi-walled carbon nanotubes; rutin; flavonoids; drug delivery; cytotoxicity
keywords	EXTRACTION
abstract	Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose-effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.
publisher	MDPI
isbn	2305-6304
year published	2021
volume	9
issue	8
digital object identifier (doi)	10.3390/toxics9080173
web of science category	10
subject category	Environmental Sciences; Toxicology
unique article identifier	WOS:000690137400001