Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts


Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose-effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.




Environmental Sciences; Toxicology


Neto, CMS; Lima, FC; Morais, RP; de Andrade, LRM; de Lima, R; Chaud, MV; Pereira, MM; Junior, RLCD; Cardoso, JC; Zielinska, A; Souto, EB; Lima, AS; Severino, P

nossos autores


This research was funded by CoordenacAo Aperfeicoamento de Pessoal de Nivel Superior (CAPES) and FundacAo de Amparo a Pesquisa do Estado de Sergipe (FAPITEC) (PROCESSO: 88887.159533/2017-00 extracAo, encapsulacAo e caracterizacAo de bioativos para o interesse biotecnologico). Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq 301964/2019-0 Chamada 06/2019, and Chamada CNPq no 01/2019). EBS received support from the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020. This research was also supported by the Poznan University of Medical Sciences.

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