authors |
Neto, CMS; Lima, FC; Morais, RP; de Andrade, LRM; de Lima, R; Chaud, MV; Pereira, MM; Junior, RLCD; Cardoso, JC; Zielinska, A; Souto, EB; Lima, AS; Severino, P |
nationality |
International |
journal |
TOXICS |
author keywords |
multi-walled carbon nanotubes; rutin; flavonoids; drug delivery; cytotoxicity |
keywords |
EXTRACTION |
abstract |
Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose-effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration. |
publisher |
MDPI |
isbn |
2305-6304 |
year published |
2021 |
volume |
9 |
issue |
8 |
digital object identifier (doi) |
10.3390/toxics9080173 |
web of science category |
10 |
subject category |
Environmental Sciences; Toxicology |
unique article identifier |
WOS:000690137400001
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
3.271 |
5 year journal impact factor |
Not Available |
category normalized journal impact factor percentile |
65.616 |
dimensions (citation analysis):
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altmetrics (social interaction):
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