NiTi laser textured implants with improved in vivo osseointegration: An experimental study in rats


Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for os-seointegration. This work explores the use of laser to fabricate NiTi textured implants, testing two dif-ferent groove-based designs. Their performance was evaluated in vivo through implantation in Sprague Dawley rats' femur, being then analyzed after 4 and 12 weeks of implantation. Push-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured NiTi. Histology showed that, at 4 weeks of implantation, mainly immature woven bone was present whilst at 12 weeks a more mature bone had developed. Con-sidering the largest implantation time (12 weeks), results showed extraction forces considerably higher for textured implants (G2 and G3). Moreover, when comparing G2 and G3, it was found that G2 (having the highest textured surface area) displayed the maximum extraction force among all groups, with an increase of 212% when compared to non-textured implants (G1). These results prove that the design and manufacturing technology are effective to promote an im -proved bone-implant bond, aiming the development of orthopedic implants. (c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.




Materials Science; Metallurgy & Metallurgical Engineering


Costa, MM; Miranda, A; Bartolomeu, F; Carvalho, O; Matos, S; Miranda, G; Silva, FS

nossos autores


The authors would like to thank the Hard Tissue Laboratory of the Dentistry School of the Faculty of Medicine of the Uni-versity of Coimbra, specially to Mrs Claudia Brites for the his-tological specimens processing. This work was supported by FCT through the grants (No. SFRH/BD/140191/2018) , the project No. PTDC/EME-EME/14 42/2020 (Add2MechBio) and also by the project No. PTDC/EME-EME/30498/2017 (FunImp) . Moreover, this work has been also funded by National funds, through the Foundation for Science and Technology (FCT) (project Nos. UIDB/50026/2020 and UIDP/50026/2020. Finally, this work was supported by FCT national funds, under the national support to R&D units grant, through the reference projects (Nos. UIDB/04436/2020 and UIDP/04436/2020) .

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