resumo
Plant sterols (PS) are cholesterol-like terpenoids widely spread in the kingdom Plantae. Being the target of extensive research for more than a century, PS have topped with evidence of having beneficial effects in healthy subjects and applications in food, cosmetic and pharmaceutical industries. However, many gaps in several fields of PS's research still hinder their widespread practical applications. In fact, many of the mechanisms associated with PS supplementation and their health benefits are still not fully elucidated. Furthermore, compared to cholesterol data, many complex PS chemical structures still need to be fully characterized, especially in oxidized PS. On the other hand, PS molecules have also been the focus of structural modifications for applications in diverse areas, including not only the above-mentioned but also in e.g., drug delivery systems or alternative matrixes for functional foods and fats. All the identified drawbacks are also superimposed by the need of new PS sources and technologies for their isolation and purification, taking into account increased environmental and sustainability concerns. Accordingly, current and future trends in PS research warrant discussion.
palavras-chave
PHYTOSTEROL OXIDATION-PRODUCTS; PRESSURE CHEMICAL-IONIZATION; MASS-SPECTROMETRY METHOD; CHROMATOGRAPHY-GAS CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; BETA-SITOSTEROL OXIDES; COLORECTAL-CANCER RISK; FATTY-ACID ESTERS; ESI-MS/MS METHOD; CHOLESTEROL ABSORPTION
categoria
Biochemistry & Molecular Biology; Chemistry
autores
Evtyugin, DD; Evtuguin, DV; Casal, S; Domingues, MR
nossos autores
Dmitry Dmitrievitch Evtyugin
Estudante de doutoramento
Dmitry Evtyugin
Professor Associado com Agregaçãoagradecimentos
Thanks are due to CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020),LAQV-REQUIMTE, FCT Ref. UIDB/50006/2020 & amp; UIDP/50006/2020, CICECO-Aveiro Institute ofMaterials, UIDB/50011/2020 & amp; UIDP/50011/2020, and to RNEM, Portuguese Mass SpectrometryNetwork (LISBOA-01-0145-FEDER-402-022125) financed by national funds through the Portuguese Foundation for Science and Technology (FCT)/MCTES