resumo
Graphene is emerging in numerous wearable and biomedical applications. Understanding the impact of graphene-based nanocomposites over bacterial activity is critical for design appropriate technical solutions. In this work, antibacterial activity of monolayer and few-layer graphene is tested against Gram-negative and Gram-positive model bacteria. Such graphene-based nanomaterials present different effects on bacteria viability, depending on concentration and shape. The presence of dopant agents can either increase or revert graphene antibacterial effect. Among other bactericidal mechanisms, we also demonstrate that graphene surface polarity is connected to antibacterial properties and can be easily modified by surface charge transfer doping. This electrophilicity tuning offers a novel mechanism for the molecular basis of graphene's antibacterial activity.
palavras-chave
LIGHT-EMITTING-DIODES; ESCHERICHIA-COLI; OXIDE; MECHANISMS; NANOSHEETS; LAYER
categoria
Science & Technology - Other Topics; Materials Science
autores
Rodrigues, DP; Moreirinha, C; Rajan, G; Neves, AIS; Freitas, SC; Sequeira, S; Russo, S; Craciun, MF; Almeida, A; Alves, H
nossos autores
Catarina Moreirinha
Bolseiro de pós-Doutoramento
Helena Alves
Investigador Principal
Sara Isabel Holbeche Sequeira
Estudante de doutoramentoProjectos
Single Crsytal Solar Cell (IF/01088/2014)
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Sensores de temperatura, gases e humidade baseados em grafeno para a eletronica têxtil (Graphsense)
agradecimentos
Fundacao para a Ciencia e a Tecnologia, Grant/Award Numbers: SFRH-BD-129827-2017, IF/01088/2014, UIDB/50011/2020, UIDP/50011/2020; Fundo Regional para a Ciencia e Tecnologia, Grant/Award Numbers: POCI-01-0145-FEDER-032072, POCI-01-0247-FEDER-033126, PCIF/SSO/0163/2019; Engineering and Physical Sciences Research Council, Grant/Award Numbers: EP/S019855/1, EP/M001024/1, EP/M002438/1