resumo
During the past decade, ionic-liquid-based Aqueous Biphasic Systems (ABS) have been the focus of a significant amount of research. Based on a compilation and analysis of the data hitherto reported, this critical review provides a judicious assessment of the available literature on the subject. We evaluate the quality of the data and establish the main drawbacks found in the literature. We discuss the main issues which govern the phase behaviour of ionic-liquid-based ABS, and we highlight future challenges to the field. In particular, the effect of the ionic liquid structure and the various types of salting-out agents (inorganic or organic salts, amino acids and carbohydrates) on the phase equilibria of ABS is discussed, as well as the influence of secondary parameters such as temperature and pH. More recent approaches using ionic liquids as additives or as replacements for common salts in polymer-based ABS are also presented and discussed to emphasize the expanding number of aqueous two-phase systems that can actually be obtained. Finally, we address two of the main applications of ionic liquid-based ABS: extraction of biomolecules and other added-value compounds, and their use as alternative approaches for removing and recovering ionic liquids from aqueous media.
palavras-chave
298.15 K EXPERIMENT; 2-PHASE SYSTEMS; PHASE-BEHAVIOR; SALTING-OUT; 1-BUTYL-3-METHYLIMIDAZOLIUM BROMIDE; POLYETHYLENE-GLYCOL; AMINO-ACIDS; PLUS WATER; TETRABUTYLAMMONIUM BROMIDE; PARTITIONING BEHAVIOR
categoria
Chemistry
autores
Freire, MG; Claudio, AFM; Araujo, JMM; Coutinho, JAP; Marrucho, IM; Lopes, JNC; Rebelo, LPN
nossos autores
Ana Filipa M. Cláudio
Bolseiro de pós-Doutoramento
Isabel Maria Delgado Jana Marrucho Ferreira
Professor Catedrático
Mara Guadalupe Freire Martins
Investigador CoordenadorGrupos
G4 - Materiais Renováveis e Economia Circular
G5 - Materiais Biomiméticos, Biológicos e Vivos
Projectos
agradecimentos
This work was financed by national funding from FCT - Fundacao para a Ciencia e a Tecnologia, through projects PTDC/QUI-QUI/121520/2010 and Pest-C/CTM/LA0011/2011. The authors also acknowledge FCT for the post-doctoral and doctoral grants SFRH/BPD/41781/2007, SFRH/BPD/65981/2009, and SFRH/BD/74503/2010 of M. G. Freire, J. M. M. Araujo and A. F. M. Claudio.