Diamond based biosensors: surface-fluid interaction issues


The interaction of nanocrystalline (NCD) and microcrystalline (MCD) p-type semiconducting diamond surfaces with phosphate buffer saline (PBS), simulated body fluid (SBF) and bovine serum albumin (BSA) solutions under applied electric potentials is the main subject of this work. The effect of these fluids on the electrical resistivity of the diamond surface is evaluated. Furthermore, the interaction effects of these surfaces with BSA containing SBF solution during 30 days, is addressed. The electrical measurements have shown that the electrical current passing through the NCD samples is influenced by the fluid's ionic composition, whereas no variation was detected for the MCD samples. Both NCD and MCD surfaces favor the formation of a deposit layer after 30 days in contact with SBF+BSA solution. This deposit is mainly composed of Ca, P, Mg and O, containing also a significant concentration of BSA proteins. (C) 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of the Institute of Bio-Sensing Technologies, UWE Bristol.




Biophysics; Chemistry


Neto, MA; Gomes, CMF; Silva, EL; Fernandes, AJS; Oliveira, FJ; Silva, RF

nossos autores


This work was supported by project PTDC/CTM-MET/113645/2009, funded by FEDER through COMPETE programmme-Operacional Factors for Competitivity and by national funds through FCT Portuguese Science and Technology Foundation M. A. Neto and E. L. Silva would like to acknowledge, respectively, the grants SFRH/BPD/45610/2008 and SFRH/BD/61675/2009 from FCT - Fundacao para a Ciencia e a Tecnologia

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