Cell-based soft biomaterials

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abstract

Cell-based tissue engineering (TE) has been rapidly evolving to meet the demand of scaffold-free regenerative tissues. Commonly used scaffold-based strategies are often associated with delayed tissue formation, rejection and tissue failure. Scaffold-free TE is a bottom-up methodology that makes use of cell-based soft biomaterials such as cell sheets(CS), spheroids or multishaped microtissues and fiber-shaped multicellular aggregates as building blocks for the construction of functional biomimetic 3D heterogeneous tissues(i.e. consisting of different cell types). Cell-based soft biomaterials are a type of scaffold-free tissues where biomaterials may be used to stimulate and help to orchestrate predetermined functions of natural tissues. The following sections will explore the different cell-based or scaffold-free systems, their advantages, challenges, methods and applications. Major advances in the scaffold-free field resulting from the well-architectured combination of the different methodologies are also reported.

authors

A. Sofia Silva, Lúcia F. Santos, Mariana B. Oliveira and João F. Mano

our authors

foto Ana Sofia Matias da Silva

Ana Sofia Matias da Silva

Assistant Researcher
foto João Mano

João Mano

Vice Director

Groups

G5 - Biomimetic, Biological and Living Materials

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Publication Details

type
Book Chapter
year
2021
Book Title
Soft Matter for Biomaterial Applications
isbn
978-1-78801-757-2
book digital object identifier
10.1039/9781839161124-00720
link
https://pubs.rsc.org/en/content/chapter/bk9781788017572-00720/978-1-78801-757-2

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