Modificação da superfície de nanofios magnéticos para bioaplicações


Quasi one-dimensional (1D) nanostructures have attracted great attention because they can be used to fabricate new functional devices. In this thesis chemical strategies for the synthesis and surface functionalization of nickel nanowires have been investigated. Hence, nickel nanowires were first synthesized by electrodeposition in alumina template. This template was prepared from an aluminum foil by a process that involves a two-step anodization process and that leads to the formation of a nanoporous alumina layer where the metal was deposited. The Ni nanowires were then surface modified with the polyelectrolyte (polyethyleinimine- PEI) which has been previously functionalized with a fluorophore (fluorescein isothiocyanate- FITC). Considering the ferromagnetic properties of Ni nanowires, the funcionalized materials have potential for bio-applications such as simultaneous magnetic separation and biolabelling of cells. Therefore, preliminary experiments were carried out to demonstrate the proof of concept by biofunctionalization of modified Ni nanowires and their conjugation to bovine blood platelets as a model system.


Paula Cristina de Almeida Pinheiro

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Tito Trindade


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