Innovative Sensor for Rapid Detection of L-Asparagine bears the CICECO signature
Ana Paula Tavares, Mara Freire, Márcia Neves, and João C.F. Nunes, researchers from CICECO – Aveiro Institute of Materials and the Department of Chemistry, have developed a simple and cost-effective colorimetric sensor capable of visually detecting the presence and concentration of L-asparagine in aqueous solutions, without the need for sophisticated laboratory equipment.Ana Paula Tavares, Mara Freire, Márcia Neves, and João C.F. Nunes, researchers from CICECO – Aveiro Institute of Materials and the Department of Chemistry, have developed a simple and cost-effective colorimetric sensor capable of visually detecting the presence and concentration of L-asparagine in aqueous solutions, without the need for sophisticated laboratory equipment. L-asparagine is an amino acid found in the human body and in plant-based foods, particularly those rich in starch, such as potatoes and cereals. Its quantification is essential in both laboratory and clinical settings.
This sensor represents a practical alternative to conventional techniques, which are usually complex, time-consuming, and expensive.
L-asparagine is present in the human body and in starchy plant-based foods. In the healthcare sector, monitoring its levels is associated with the follow-up of patients with acute lymphoblastic leukemia. In the food industry, controlling its presence is crucial to prevent the formation of acrylamide — a potentially carcinogenic substance formed during the cooking of certain foods at temperatures above 100 °C.
The technology consists of a sensor material that changes color according to the amount of L-asparagine present in the solution. The concentration can be read instantly by simply observing the color change, without the need for laboratory equipment. Due to its simplicity, portability, and low cost, this innovation paves the way for its application in various contexts, from research laboratories to factories and hospital units.
This development emerged from the project “NanoPurAsp – Development of sustainable nanomaterials for the purification of antileukemic drugs,” funded by the Foundation for Science and Technology (FCT) and the POCI program. It also received support from the UI-TRANSFER project, which aims to promote the valorization and transfer of scientific knowledge. This support allowed the team to conduct proof-of-concept tests and prepare the technology for future market applications.
The invention’s potential has been internationally recognized, with the European Patent Office issuing a notice of intention to grant the patent. The University of Aveiro has already secured validation under the European unitary patent system, ensuring the protection of the technology in several European Union countries.
This innovation stands out as a useful, versatile, and sustainable tool with the potential to have a significant impact across multiple sectors, promoting public health and food safety in a simple, fast, and efficient way.
(Photo: from left to right: Ana Paula Tavares, Mara Freire, João C.F. Nunes, and Márcia Neves)