Emanuel V. Capela

Junior Researcher

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  • Chemistry
  • 29.3.3 | 29.3.24

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Short CV

Emanuel V. Capela is currently a Junior Researcher at the research group "Process and Product Applied Thermodynamics" (PATh), CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal. 
His research interests are mainly focused in the production of monoclonal antibodies (mAbs) by mammalian cell technology and in the design of integrated downstream bioprocesses, for the selective extraction and purification of mAbs directly from the complex medium, envisaging the process integration and intensification. Moreover, he has been working with a new class of solvents, ionic liquids, where his scientific interest devoted to these compounds includes the characterization of their properties and the evaluation of their potential in the establishment of extractive platforms for value-added compounds, in particular for biopharmaceuticals. Currently, his research activities are also focused on the InsectERA Agenda - a project with a consortium of 38 entities (companies and universities/institutes), that aims to foster the circular economy and leverage the development of new products, processes and services, based on R&D and innovation, with high added-value and incorporation of knowledge and technology, allowing to meet the challenge of the green transition towards environmental sustainability.
Born on 24 of June of 1993 at Porto, Portugal, obtained his BSc degree in Biochemistry from University of Aveiro, Portugal, in 2014, his MSc degree in Biochemistry - Biomolecular Methods from the same institution in 2016, and his PhD in Chemical Engineering/Bioengineering from the University of Aveiro, Portugal in collaboration with Instituto Superior Técnico, University of Lisbon, Portugal, in 2022.

Academic degrees

2017 - 2022 | PhD in Chemical Engineering, specialization in Bioengineering | University of Aveiro and Instituto Superior Técnico - University of Lisbon | Thesis title: "Innovative and sustainable platforms for the downstream processing of antibody-based biopharmaceuticals", supervised by Dr. Mara G. Freire (UA) and co-supervised by Dr. Ana M. Azevedo (IST) and Prof. João A.P. Coutinho (UA).

2014 - 2016 | MSc in Biochemistry, specialization in Biomolecular Methods | University of Aveiro | Thesis title:"Production and purification of antibodies using aqueous biphasic systems composed of ionic liquids as adjuvants", supervised by Dr. Mara G. Freire (UA) and co-supervised by Dr. Ana M. Azevedo (IST) and Prof. M. Raquel Aires-Barros (IST).

2011 - 2014 | BSc in Biochemistry | University of Aveiro | Project title: "Purification of antibodies using aqueous biphasic systems", supervised by Dr. Mara G. Freire (UA) and co-supervised by Master Mafalda R. Almeida (UA).

Previous scientific and/or professional activities

2024 - Currently | Junior Researcher | Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Portugal

2022 - 2024 | Innovation Project Manager (Associate Consultant) | Frederico Mendes & Associados - Sociedade de Consultores, Lda.

2021 - 2022 | Research Associate | FairJourney Biologics, S.A.

2017 - 2021 | PhD Researcher | Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Portugal and Department of Bioengineering, Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), University of Lisbon, Portugal.

2018 | Guest Researcher | Sustainable Research Technology (SPT) group, Faculty of Science and Technology (TNW), University of Twente, The Netherlands.

2016 - 2017 | Research Assistant | Department of Bioengineering, Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), University of Lisbon, Portugal.

2015 - 2016 | MSc Researcher | Department of Bioengineering, Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), University of Lisbon, Portugal.

2014 | BSc Researcher | Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Portugal.

Ongoing Supervisions

Ana Miguel da Silva Loureiro

PhD Student

Publications

Using three-phase partitioning for the purification and recovery of antibodies from biological media

Capela, EV; Magnis, I; Rufino, AFCS; Torres-Acosta, MA; Aires-Barros, MR; Coutinho, JAP; Azevedo, AM; Silva, FAE; Freire, MG
2023, SEPARATION AND PURIFICATION TECHNOLOGY, 316.

Supported ionic liquids as customizable materials to purify immunoglobulin G

Capela, EV; Bairos, J; Pedro, AQ; Neves, MC; Aires-Barros, MR; Azevedo, AM; Coutinho, JAP; Tavares, APM; Freire, MG
2023, SEPARATION AND PURIFICATION TECHNOLOGY, 305.

Double-Stimuli-Responsive (Temperature and pH) Aqueous Biphasic Systems Comprising Ionic Liquids

Rufino, AFCS; Bola, JM; Coutinho, JAP; Silva, FAE; Freire, MG; Capela, EV
2023, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 11, 16, 6343-6351.

An Overview on the Recent Advances in Alternative Solvents as Stabilizers of Proteins and Enzymes

Almeida, JS; Capela, EV; Loureiro, AM; Tavares, APM; Freire, MG
2022, CHEMENGINEERING, 6, 4.

Opposite effects induced by cholinium-based ionic liquid electrolytes in the formation of aqueous biphasic systems comprising polyethylene glycol and sodium polyacrylate

Bernardo, SC; Capela, EV; Pereira, JFB; Ventura, SPM; Freire, MG; Coutinho, JAP
2021, MOLECULES, 26, 21.
ISBN: 1420-3049

Insights on the laccase extraction and activity in ionic-liquid-based aqueous biphasic systems

Capela, EV; Valente, AI; Nunes, JCF; Magalhaes, FF; Rodriguez, O; Soto, A; Freire, MG; Tavares, APM
2020, SEPARATION AND PURIFICATION TECHNOLOGY, 248.
ISBN: 1873-3794

Sustainable strategies based on glycine-betaine analogue ionic liquids for the recovery of monoclonal antibodies from cell culture supernatants

Capela, EV; Santiago, AE; Rufino, AFCS; Tavares, APM; Pereira, MM; Mohamadou, A; Aires-Barros, MR; Coutinho, JAP; Azevedo, AM; Freire, MG
2019, GREEN CHEMISTRY, 21, 20, 5671-5682.
ISBN: 1463-9270

A simple approach for the determination and characterization of ternary phase diagrams of aqueous two-phase systems composed of water, polyethylene glycol and sodium carbonate.

Capela, Emanuel V; Santos, Joao H P M; Boal-Palheiros, Isabel; Coutinho, Joao A P; Ventura, Sonia P M; Freire, Mara G
2019, CHEMICAL ENGINEERING EDUCATION, 53, 2, 112-120.
ISBN: 2165-6428

LYTAG-driven purification strategies for monoclonal antibodies using quaternary amine ligands as affinity matrices

Campos-Pinto, I; Capela, EV; Silva-Santos, AR; Rodriguez, MA; Gavara, PR; Fernandez-Lahore, M; Aires-Barros, MR; Azevedo, AM
2018, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 93, 7, 1966-1974.

Mechanisms ruling the partition of solutes in ionic-liquid-based aqueous biphasic systems - the multiple effects of ionic liquids

Passos, H; Dinis, TBV; Capela, EV; Quental, MV; Gomes, J; Resende, J; Madeira, PP; Freire, MG; Coutinho, JAP
2018, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 20, 13, 8411-8422.

Nucleic Acids Stabilization with Ionic Liquids and Deep Eutectic Solvents

In Noureddine Abidi and Julia Shamshina (Eds.), Properties and Applications of Ionic Liquids
Almeida J.S.; Capela E.V.; Tavares A.P.M.; Freire M.G.
2023, Properties and Applications of Ionic Liquids, 181-218, Nova Science Publisher Inc..
ISBN: 979-888697873-5; 979-888697635-9

Monoclonal Antibodies as Therapeutic Agents for Inflammatory Diseases

In Atta-ur-Rahman (Eds.), Frontiers in Clinical Drug Research: Anti-Infectives
Bairos, J; Capela, EV; Tavares, APM; Freire, MG
2021, 1-54, Sharjah, UAE, Bentham Science.
ISBN: 978-981-5039-42-9

Application of Ionic Liquids in Separation and Fractionation Processes

In Buxing Han and Tianbin Wu (Eds.), Green Chemistry and Chemical Engineering
Capela, EV; Coutinho, JAP; Freire, MG
2019, 637-665, New York, NY, Springer.
ISBN: 978-1-4939-9059-7

Application of Ionic Liquids in Separation and Fractionation Processes

In Robert A. Meyers (Eds.), Encyclopedia of Sustainability Science and Technology
Capela, EV; Coutinho, JAP; Freire, MG
2018, 1-29, New York, USA, Springer.
ISBN: 978-1-4939-2493-6

Monoclonal Antibodies – Addressing the Challenges on the Manufacturing Processing of an Advanced Class of Therapeutic Agents

In Atta-ur-Rahman (Eds.), Frontiers in Clinical Drug Research-Anti Infectives
Capela, EV; Aires-Barros, MR; Freire, MG; Azevedo, AM
2017, 142-203, Sharjah, UAE, Bentham Science.
ISBN: 978-1-68108-488-6

Innovative and sustainable platforms for the downstream processing of antibody-based biopharmaceuticals

Emanuel V. Capela
2022, supervised by Dr. Mara G. Freire, Dr. Ana M. Azevedo, Prof. João A.P. Coutinho.

Production and purification of antibodies using aqueous biphasic systems composed of ionic liquids as adjuvants

Emanuel V. Capela
2016, supervised by Dr. Mara G. Freire, Dr. Ana M. Azevedo, Prof. M. Raquel Aires-Barros.

Purification of antibodies using aqueous biphasic systems

Emanuel V. Capela
2014, supervised by Dr. Mara G. Freire, Master Mafalda R. Almeida.

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