Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models

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Project Details

Start date
2020-09-01
End date
2022-02-28
Extended date
2022-10-31
%
Acronym
AMNIOGEL
Reference
957585
Funding
European Comission
Programme
ERC-2019-POC - ERC Proof of Concept Grant
Budget
150.000 €
Our budget
150.000 €

Team

Description

The aim of ‘AMNIOGEL’ is the development of human extracellular matrix (ECM) based materials, as radically innovative,highly versatile human-derived platforms for 3D cell culture, microtissue development and disease models establishment. Inparticular, we will develop 3D disease models that could be used as an enabling tool for personalized drug discovery,increasing our understanding of the mechanisms behind bone cancer.The proposed cutting-edge technology enables the culture of human cells in a physiologically relevant microenvironment forapplications in cell culture research, drug screening and development, cancer research, tissue engineering, replacement ofanimal testing and therapeutic applications. The potential of this technology to reduce or completely replace use of animalsfor biological screenings is expected to havea significant impact in the 3D cell culture market and pharmaceutical industryby accelerating drug screening and development reducing associated costs. The innovation potential of our products isbased on the fact that contain human biochemical cues (vital for cell function), is a complete xeno-free solution (avoidscontamination) for human cell culture and easy to manipulate. It is worth mentioning that offers the possibility to bepersonalised (using the patient’s own ECM) according to the customer needs. Moreover, our culture substrates are easilyprocessed in multiple geometries and in microarrays amenable to ‘organ-on- a-chip’ systems designed for high-throughputscreening (HTS) applications.

Coordinator

João Mano

Coordination

Universidade de Aveiro (UA)

Partners

no

Groups

G5 - Biomimetic, Biological and Living Materials;

Outputs

Sponsors

Sponsors
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