Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis

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abstract

This work reports research on the development of bimodal magnetic and fluorescent 1D nanoprobes. First, ferromagnetic nickel nanowires (NiNW) have been prepared by Ni electrodeposition in an anodic aluminum oxide (AAO) template. The highly ordered self-assembled AAO nanoporous templates were fabricated using a two-step anodization method of aluminum foil. The surface of the NiNW were then modified with polyethyleneimine (PEI) which was previously labeled with an organic dye (fluorescein isothiocyanate: FITC) via covalent bonding. The ensuing functionalized NiNW exhibited the characteristic green fluorescence of FITC and could be magnetically separated from aqueous solutions by using a NdFeB magnet. Finally, the interest of these bimodal NiNW as nanoprobes for in vitro cell separation and biolabeling was preliminary assessed in a proof of principle experiment that involved the attachment of bio-functionalized NiNW to blood cells. (C) 2013 Elsevier Inc. All rights reserved.

keywords

MAGNETIC NANOWIRES; BIOLOGICAL APPLICATIONS; NI NANOWIRES; NANOPARTICLES; ARRAYS; SEPARATIONS; SURFACE; NANOMATERIALS; MANIPULATION; FABRICATION

subject category

Chemistry

authors

Pinheiro, PC; Sousa, CT; Araujo, JP; Guiomar, AJ; Trindade, T

our authors

foto Paula Pinheiro

Paula Pinheiro

Research Fellowship
foto Tito Trindade

Tito Trindade

Full professor

Groups

G1 - Porous Materials and Nanosystems

Projects

Integrated Lab on Chip Platforms for Medical Diagnostics (Luso-Spain Network) (NANO/NMED-SD/0140/2007)

Magnetotransduction: development of magnetic nanoparticles-viral vector complexes for therapeutic gene delivery in the senile brain (EULANEST European-Latin American Network for Science and Technology) (NEURONANO)

Centre for Research in Ceramics and Composite Materials - CICECO (LA0011: 2011-2012) (PEst-C/CTM/LA0011/2011)

acknowledgements

We thank Fundacao para a Ciencia e Tecnologia (NANO/NMed-SD/0140/2007, ERA-Eula/0003/2009 and Pest-C/CTM/LA0011/2011), FSE and POPH for funding. We also thank Luisa Cortes (Center for Neurosciences and Cell Biology, Coimbra, Portugal) for valuable technical assistance with the microscope. Celia T. Sousa is also thankful to FCT for post-doctoral grant SFRH/BPD/82010/2011.

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Publication Details

type
Journal Article
year
2013
journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
volume
410
publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
issn
0021-9797
digital object identifier
10.1016/j.jcis.2013.07.065
web of science article identifier
WOS:000325056700003

Journal Metrics (JCR 2019)

Journal Impact Factor
7.489
Journal Impact Factor (5 yrs)
6.171
category normalized journal percentile
80.818

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