abstract
Nano rods of magnesium-doped hydroxyapatite, Ca10-xMgx(PO4)(6)(OH)(2)(Mg-x-HA, x = 0-1.0), were successfully synthesized through cetyltrimethyl ammonium bromide assisted hydrothermal synthesis method. X-ray diffraction, infrared spectroscopy, thermogravimetric analysis and transmission electron microscopy, provided experimental evidences about the effects of Mg-doping on the phase assemblage, crystallite size, morphology, specific surface area of Mg-doped hydroxyapatite nanopowders. The replacement Ca2+ ions by smaller Mg2+ ones caused lattice shrinkage and lattice strains that enhanced the solubility and the in vitro bio-mineralisation activity upon immersing sintered samples in simulated body fluid. The severity of these structural changes rose with increasing Mg-doping and enable tailoring the in vitro biological activity enabling selecting the most suitable material for bone grafts and tissue engineering applications.
keywords
MAGNESIUM-SUBSTITUTED HYDROXYAPATITE; TRICALCIUM PHOSPHATE; DRUG-DELIVERY; IN-VITRO; CALCIUM ORTHOPHOSPHATES; BIOMEDICAL APPLICATIONS; THERMAL-BEHAVIOR; AQUEOUS-MEDIUM; BONE; NANOPARTICLES
subject category
Cell Biology
authors
Bricha, M; Belmamouni, Y; Essassi, E; Ferreira, JMF; El Mabrouk, K
our authors
José Maria da Fonte Ferreira
Retired Professoracknowledgements
This work is financially supported by MASCIR-Moroccan Foundation for Advanced Science Innovation and Research. The support from CICECO is also acknowledged.