abstract
Bacterial cellulose (BC) membranes were explored as novel nanostructured transdermal delivery systems for diclofenac sodium salt (a typical non-steroidal anti-inflammatory drug). Diclofenac sodium salt loaded BC membranes were prepared through a simple methodology, using glycerol as plasticizer, and characterized in terms of structure, morphology and swelling behavior. The membranes were very homogeneous, quite flexible and presented a considerably higher swelling behavior when compared with pure BC. In vitro diffusion studies with Franz cells, were conducted using human epidermal membranes, and showed that the incorporation of diclofenac in BC membranes provided similar permeation rates to those obtained with commercial patches and substantially lower than those observed with a commercial gel. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes clearly indicates the enormous potentialities of using BC membranes for transdermal administration of diclofenac. (C) 2014 Elsevier Ltd. All rights reserved.
keywords
BIOMEDICAL APPLICATIONS; BIOCELLULOSE MEMBRANES; RELEASE; SODIUM; VIVO; NANOCELLULOSE; BIOPOLYMER; LIDOCAINE
subject category
Chemistry; Polymer Science
authors
Silva, NHCS; Rodrigues, AF; Almeida, IF; Costa, PC; Rosado, C; Neto, CP; Silvestre, AJD; Freire, CSR
our authors
Armando Jorge Domingues Silvestre
Full professor
Carlos Pascoal Neto
Raiz Director
Carmen Sofia da Rocha Freire Barros
Coordinating Researcher
Nuno Helder da Cruz Simões Silva
Researcheracknowledgements
The authors acknowledge Fundacao para a Ciencia e a Tecnologia for CICECO (Pest-C/CTM/LA0011/2013 and SFRH/BD/85690/2012) funding. C.S.R. Freire also acknowledges FCT/MCTES for a research contract under the Program