abstract
The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.
keywords
DRUG-DELIVERY SYSTEMS; COLLAGEN/HYDROXYAPATITE COMPOSITE-MATERIALS; SYNTHESIZED IN-VITRO; LOCAL-DELIVERY; HYDROXYAPATITE/COLLAGEN COMPOSITE; MAGNETITE NANOPARTICLES; BIOMEDICAL APPLICATIONS; STAPHYLOCOCCUS-AUREUS; POROUS HYDROXYAPATITE; COLLAGEN COMPOSITES
subject category
Science & Technology - Other Topics; Pharmacology & Pharmacy
authors
Marques, C; Ferreira, JMF; Andronescu, E; Ficai, D; Sonmez, M; Ficai, A
our authors
José Maria da Fonte Ferreira
Retired Professoracknowledgements
The authors recognize financial support from the European Social Fund through the POSDRU/89/1.5/S/54785 project