Synthesis and in vitro bioactivity assessment of injectable bioglass - organic pastes for bone tissue repair


The aim of this work was to study the bioactivity of systems based on a clinically tested bioactive glass (BG) particulates (mol%: 4.33 Na2O -30.30 CaO -12.99 MgO -45.45 SiO2 -2.60 P2O5 -4.33 CaF2) and organic carriers. The cohesiveness of injectable bone graft products is of high relevance when filling complex volumetric bone defects. With this motivation behind, BG particulates with mean sizes within 11-14 mu m were mixed in different proportions with glycerol (G) and polyethylene glycol (PEG) as organic carriers and the mixtures were fully injectable exhibiting Newtonian flow behaviors. The apatite forming ability was investigated using X-ray diffraction and field emission scanning electron microscopy under secondary electron mode after immersion of samples in simulated body fluid (SBF) for time durations varying between 12 h and 7 days. The results obtained revealed that in spite of the good adhesion of glycerol and PEG carriers to glass particles during preparation stage, they did not hinder the exposure of bioactive glass particulates to the direct contact with SBF solution. The results confirmed the excellent bioactivity in vitro for all compositions expressed by high biomineralization rates with the formation of crystalline hydroxyapatite being identified by XRD after 12 h of immersion in SBF solution. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.



subject category

Materials Science


Tulyaganov, DU; Reddy, AA; Siegel, R; Ionescu, E; Riedel, R; Ferreira, JMF

our authors


The first author acknowledges financial support from the German Academic Exchange Service (DAAD organization). The authors thank Dr. M. Graczyk-Zajac of the Technical University Darmstadt FB Material - und Geowissenschaften, and Dr. O. Ruzimuradov of the Turin Polytechnic University in Tashkent, for their help with the processing SEM experiments. A. A. Reddy is indebted to the Portuguese Foundation for Science and Technology (FCT) for the PhD Grant References SFRH/BD/89915/2012.

Share this project:

Related Publications

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".