abstract
New compositions of bioactive glasses are proposed in the CaO-MgO-SiO2-Na2O-P2O5-CaF2 system. Mineralization tests with immersion of the investigated glasses in simulated body fluid (SBF) at 37A degrees C showed that the glasses favour the surface formation of hydroxyapatite (HA) from the early stages of the experiments. In the case of daily renewable SBF, monetite (CaHPO4) formation competed with the formation of HA. The influence of structural features of the glasses on their mineralization (bioactivity) performance is discussed. Preliminary in vitro experiments with osteoblasts' cell-cultures showed that the glasses are biocompatible and there is no evidence of toxicity. Sintering and devitrification studies of glass powder compacts were also performed. Glass-ceramics with attractive properties were obtained after heat treatment of the glasses at relatively low temperatures (up to 850A degrees C).
keywords
OSTEOBLAST-LIKE CELLS; SIMULATED BODY-FLUID; APATITE FORMATION; CAO-MGO-SIO2 SYSTEM; P2O5 ADDITIVES; IN-VITRO; PHOSPHATE; HYDROXYAPATITE; CERAMICS; BEHAVIOR
subject category
Engineering; Materials Science
authors
Tulyaganov, DU; Agathopoulos, S; Valerio, P; Balamurugan, A; Saranti, A; Karakassides, MA; Ferreira, JMF
our authors
José Maria da Fonte Ferreira
Retired Professoracknowledgements
A. Balamurugan is thankful to CICECO for the post-doc fellowship grant. The financial support by the Greek Secretariat of Science and Technology, in the framework of the Project ENTER 04EP26, is also acknowledged.