abstract
The optimization of simulated moving bed (SMB) units is often performed through detailed phenomenological models and require extensive computation time. Hence several optimization methods like the Triangle Theory, and the concept of separation volume have been proposed. However, they do not provide accurate results, when mass transfer limitations are significant, or require a large number of simulations. In this work, a combined Design of Experiments and Response Surface Methodology (DoE-RSM) approach is proposed for SMB optimization, aimed at providing good results with simplicity and reduced number of simulations. The separation of trans-stilbene oxide enantiomers is selected as case study in order to compare DoE-RSM with previous approaches. In the whole, accurate results are obtained with a few number of simulations, allowing for purities above 99.60% for both enantiomers, and productivity of 65.41 kg/(m(adsorbent)(3) day). The versatility of DoE-RSM tool is also discussed, emphasising their advantages and general applicability. (C) 2016 Elsevier Ltd. All rights reserved.
keywords
TROGERS BASE ENANTIOMERS; SMB CHROMATOGRAPHY; CHIRAL SEPARATION; STATIONARY-PHASE; SYSTEMS; OPERATION; OD
subject category
Computer Science; Engineering
authors
Aniceto, JPS; Cardoso, SP; Silva, CM
our authors
Carlos Manuel Silva
Associate Professor
José P. S. Aniceto
Junior Researcher
Simão Pedro Pereira Cardoso
Post-Doc Fellowshipacknowledgements
This work was developed in the scope of the project CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (Ref. FCT UID/CTM/50011/2013), financed by national funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement. Jose P.S. Aniceto and Simao P. Cardoso thank FCT for PhD grants SFRH/BD/91231/2012 and SFRH/BD/75164/2010.