Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies

authors	Santos, SC; Sigurjonsson, OE; Custódio, CA; Mano, JF
nationality	International
journal	Tissue Engineering Part B - Reviews
author keywords	platelet-rich plasma; platelets; platelet lysates; personalized medicine
keywords	PLATELET-RICH PLASMA; RANDOMIZED CONTROLLED-TRIAL; MESENCHYMAL STROMAL CELLS; FETAL BOVINE SERUM; CONTROLLED-RELEASE; ENDOTHELIAL-CELL; DOUBLE-BLIND; STEM-CELLS; LYSATE GEL; FIBRIN
abstract	Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors (GFs) and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own GFs. In the last years, a great development has been witnessed on PRP based biomaterials, with both structural and functional purposes. In this study we overview the most relevant PRP applications encompassing PRP based materials for tissue engineering and regenerative medicine. This review also summarizes the challenges in the fields of tissue engineering and regenerative medicine and provides a perspective on future directions.
publisher	MARY ANN LIEBERT, INC
issn	1937-3368
year published	2018
volume	24
issue	6
beginning page	454
ending page	462
digital object identifier (doi)	10.1089/ten.teb.2018.0008
web of science category	Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology
subject category	Cell Biology; Biotechnology & Applied Microbiology
unique article identifier	WOS:000435982800001