authors |
Santos, SC; Sigurjonsson, OE; Custódio, CA; Mano, JF |
nationality |
International |
journal |
Tissue Engineering Part B - Reviews |
author keywords |
platelet-rich plasma; platelets; platelet lysates; personalized medicine |
keywords |
PLATELET-RICH PLASMA; RANDOMIZED CONTROLLED-TRIAL; MESENCHYMAL STROMAL CELLS; FETAL BOVINE SERUM; CONTROLLED-RELEASE; ENDOTHELIAL-CELL; DOUBLE-BLIND; STEM-CELLS; LYSATE GEL; FIBRIN |
abstract |
Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors (GFs) and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own GFs. In the last years, a great development has been witnessed on PRP based biomaterials, with both structural and functional purposes. In this study we overview the most relevant PRP applications encompassing PRP based materials for tissue engineering and regenerative medicine. This review also summarizes the challenges in the fields of tissue engineering and regenerative medicine and provides a perspective on future directions. |
publisher |
MARY ANN LIEBERT, INC |
issn |
1937-3368 |
year published |
2018 |
volume |
24 |
issue |
6 |
beginning page |
454 |
ending page |
462 |
digital object identifier (doi) |
10.1089/ten.teb.2018.0008 |
web of science category |
Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology |
subject category |
Cell Biology; Biotechnology & Applied Microbiology |
unique article identifier |
WOS:000435982800001
|