Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies

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abstract

Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors (GFs) and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own GFs. In the last years, a great development has been witnessed on PRP based biomaterials, with both structural and functional purposes. In this study we overview the most relevant PRP applications encompassing PRP based materials for tissue engineering and regenerative medicine. This review also summarizes the challenges in the fields of tissue engineering and regenerative medicine and provides a perspective on future directions.

keywords

PLATELET-RICH PLASMA; RANDOMIZED CONTROLLED-TRIAL; MESENCHYMAL STROMAL CELLS; FETAL BOVINE SERUM; CONTROLLED-RELEASE; ENDOTHELIAL-CELL; DOUBLE-BLIND; STEM-CELLS; LYSATE GEL; FIBRIN

subject category

Cell Biology; Biotechnology & Applied Microbiology

authors

Santos, SC; Sigurjonsson, OE; Custódio, CA; Mano, JF

our authors

foto Catarina de Almeida Custódio

Catarina de Almeida Custódio

Assistant Researcher
foto João Mano

João Mano

Full professor
foto Sara Catarina Nunes da Silva Santos

Sara Catarina Nunes da Silva Santos

PhD Student

Groups

G5 - Biomimetic, Biological and Living Materials

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Publication Details

type
Journal Article
year
2018
journal
Tissue Engineering Part B - Reviews
volume
24
publisher
MARY ANN LIEBERT, INC
issn
1937-3368
issue
6
digital object identifier
10.1089/ten.teb.2018.0008
web of science article identifier
WOS:000435982800001

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