Nanostructured Biopolymer/Few-Layer Graphene Freestanding Films with Enhanced Mechanical and Electrical Properties

abstract

In the present work, novel freestanding multilayered films based on chitosan (CHI), alginate (ALG), and functionalized few-layer graphene are developed through layer-by-layer assembly. First, functionalized few-layer graphene aqueous suspensions are prepared from graphite by a stabilizer-assisted liquid phase exfoliation process, using a pyrene derivative as stabilizer. Afterward, the films are produced and their physical, morphological, thermal, and mechanical properties are evaluated. Furthermore, their degradation and swelling profiles, as well as their biological behavior, are assessed. The incorporation of functionalized few-layer graphene results in films with a nanolayered structure, lower roughness than the control CHI/ALG films, and hydrophilic behavior. The mechanical characterization reveals an increase of the Young's modulus, ultimate tensile strength, and elongation at break due to the incorporation of the graphene derivative. A decrease in the electrical resistivity of the multilayered films is also observed. The biological assays reveal improved cytocompatibility toward L929 cells when functionalized few-layer graphene is incorporated in the CHI/ALG matrix. Therefore, these new graphene-reinforced multilayered films exhibit interesting properties and great potential for biomedical applications, particularly in wound healing and cardiac and bone tissue engineering.

keywords

POLYELECTROLYTE MULTILAYER FILMS; FUNCTIONALIZED GRAPHENE; CROSS-LINKING; BIOMEDICAL APPLICATIONS; OXIDE NANOCOMPOSITES; POLY(METHYL METHACRYLATE); RAMAN-SPECTROSCOPY; GREEN FABRICATION; DRUG-DELIVERY; CHITOSAN

subject category

Materials Science; Polymer Science

authors

Silva, C; Caridade, SG; Cunha, E; Sousa, MP; Rocha, H; Mano, JF; Paiva, MC; Alves, NM

our authors

acknowledgements

The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) and the European program FEDER/COMPETE for the financial support through projects UID/Multi/50026/2013 and UID/CTM/50025/2013. This work was also financially supported by FCT through the scholarships SFRH/BPD/96797/2013 granted to Sofia G. Caridade, SFRH/BD/97606/2013 granted to Maria P. Sousa, and SFRH/BD/87214/2012 granted to Eunice Cunha.

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