abstract
Cationicderivativesof5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III) pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain.
keywords
ANTIMICROBIAL PHOTODYNAMIC THERAPY; GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; RESISTANT-BACTERIA; II MECHANISMS; INACTIVATION; PHOTOINACTIVATION; PORPHYRINS; PHTHALOCYANINES; INVOLVEMENT
subject category
Science & Technology - Other Topics
authors
Cardote, TAF; Barata, JFB; Amador, C; Alves, E; Neves, MGPMS; Cavaleiro, JAS; Cunha, A; Almeida, A; Faustino, MAF
our authors
Joana Filipa Brites Barata
Post-doc FellowshipGroups
acknowledgements
The authors are thankful to the University of Aveiro, to FCT/MEC for the financial support to the QOPNA Research Unit (FCT UID/QUI/00062/2013) and Centre for Environmental and Marine Studies (CESAM) unit (project Pest-C/MAR/LA0017/2013), through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and also to the Portuguese NMR Network. E.A. and J.F.B.B. also thank FCT for their PhD (SFRH/BD/41806/2007) and Post-Doc (SFRH/BPD/63237/2009) grants, respectively.