Bioactive Hydrogel Marbles
authors Leite, AJ; Oliveira, NM; Song, WL; Mano, JF
nationality International
journal SCIENTIFIC REPORTS
keywords LIQUID MARBLES; MC3T3-E1 CELLS; SURFACE; DIFFERENTIATION; GLASS; FABRICATION; GENERATION; MONOLAYER; MECHANISM
abstract Liquid marbles represented a significant advance in the manipulation of fluids as they used particle films to confine liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifically, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efficient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering.
publisher NATURE PUBLISHING GROUP
issn 2045-2322
year published 2018
volume 8
digital object identifier (doi) 10.1038/s41598-018-33192-6
web of science category Multidisciplinary Sciences
subject category Science & Technology - Other Topics
unique article identifier WOS:000447125400037
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.998
5 year journal impact factor 4.576
category normalized journal impact factor percentile 76.761
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