Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

abstract

Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, topodiscs, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.

keywords

MESENCHYMAL STEM-CELLS; SUBSTRATE TOPOGRAPHY; NANOSCALE; MICROPARTICLES; MORPHOLOGY; BEHAVIOR

subject category

Chemistry; Science & Technology - Other Topics; Materials Science; Physics

authors

Bjorge, IM; Choi, IS; Correia, CR; Mano, JF

our authors

acknowledgements

I. M. Bjorge acknowledges the Portuguese Foundation for Science and Technology (FCT) with doctoral grant SFRH/BD/129224/2017. This work was financially supported by the European Research Council grant agreement ERC-2014-ADG-669858 (ATLAS) and FCT grant agreement PTDC/BTM-MAT/31064/2017 (CIRCUS). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. I. S. Choi acknowledges the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (MSIP 2012R1A3A2026403).

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