abstract
Polyoxometalates (POMs) are metal-oxide inorganic clusters, mostly anionic, where the metal is usually a transition metal (such as V, W, or Mo). Owing to their great variety of structures and large range of molecular dimensions, POMs have attracted considerable attention over the years. The high solubility in water together with the extent of their redox chemistry make POMs and their composites very versatile materials that find many applications in the biomedical field such as drug delivery systems or anti-viral and anti-tumoural agents. While the antitumoural activity of POMs and their derivatives is well documented, their application in emergent cancer therapies has not been addressed. This review presents the application of POM-based composites as photothermal agents, radiosensitisers, and biosensors. The latest advances in the design of novel POM nanocomposites for cancer theranostics are also highlighted.
keywords
RESISTANT STAPHYLOCOCCUS-AUREUS; TUMOR MICROENVIRONMENT; ANTIBACTERIAL ACTIVITY; BLOOD-GLUCOSE; NANOMATERIALS; PLATFORM; RADIOSENSITIZATION; POLYOXOTUNGSTATE; RADIORESISTANCE; NANOSTRUCTURES
subject category
Chemistry
authors
Guedes, G; Wang, SQ; Santos, HA; Sousa, FL
our authors
Filipa Lourosa Sousa
Junior Researcher
Gabriela Guedes
Research FellowshipProjects
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
Multidimensional thermal rectifiers based on assembly of anisotropic polyoxometalates (THERMOPOMs)
acknowledgements
We acknowledge SERVIER MEDICAL ART under the Creative Commons Attribution 3.0 Unported License for the images used to build Figure 3 and TOC. The cell image in TOC is from. This work was developed within the scope of the projects ThermoPOMs P2020-PTDC-QEQ-QIN-5975-2014 and CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. F. L. S. acknowledges FCT for the IF/01533/2015 grant. H.A.S. acknowledges financial support from the HiLIFE Research Funds and the Sigrid Juselius Foundation.