[Ga83+Sm23+, Ga83+Tb23+] Metallacrowns are Highly Promising Ratiometric Luminescent Molecular Nanothermometers Operating at Physiologically Relevant Temperatures


Nanothermometry is the study of temperature at the submicron scale with a broad range of potential applications, such as cellular studies or electronics. Molecular luminescent-based nanothermometers offer a non-contact means to record these temperatures with high spatial resolution and thermal sensitivity. A luminescent-based molecular thermometer comprised of visible-emitting Ga3+/Tb(3+)and Ga3+/Sm(3+)metallacrowns (MCs) achieved remarkable relative thermal sensitivity associated with very low temperature uncertainty ofS(r)=1.9 % K(-1)and delta T<0.045 K, respectively, at 328 K, as an aqueous suspension of polystyrene nanobeads loaded with the corresponding MCs. To date, they are the ratiometric molecular nanothermometers offering the highest level of sensitivity in the physiologically relevant temperature range.



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Salerno, EV; Zeler, J; Eliseeva, SV; Hernandez-Rodriguez, MA; Neto, ANC; Petoud, S; Pecoraro, VL; Carlos, LD

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This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, financed by Portuguese funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. Financial support from the European Union's Horizon 2020 FET Open programme under grant agreement no. 801305 is also acknowledged. A.N.C.N. thanks SusPhotoSolutions project, CENTRO-01-0145-FEDER-000005, Portugal for his grant. The authors acknowledge R.A.S. Ferreira (University of Aveiro) for her help with the luminescence lifetime measurements and analysis. V.L.P. thanks NSF grant CHE-1664964. E.V.S. thanks the Rackham Graduate School for international travel funding as well as NSF grant DGE-1256260. We thank Le Studium Loire Valley Institute for Advanced Studies for the award of a LE STUDIUM Research Consortium Lanthanide-Based Agents for Sensitive and Selective Near-Infrared Imaging of Living Biologicals Systems. S.P. acknowledges support from the Institut National de la Sante et de la Recherche Medicale (INSERM). The work in Orleans has been supported by la Ligue Contre le Cancer, La Region Centre and Reseau Molecules Marines, Metabolisme & Cancer of Canceropole Grand Ouest.

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