abstract
Nanosized bioactive glass (NBG) particles are attractive materials for bone repair because of their ability to enhance bone formation and to chemically bond to the surrounding bone tissue. In recent years, composites of biopolymers and NBG particles have been developed for bone tissue engineering due to their increased bioactivity, biocompatibility, and biodegradability. In this paper, the authors review current knowledge regarding polymer/NBG composites, including nanoscale-related features and ion-release effects of bioactive glass (BG) with respect to osteogenic and angiogenic responses in vivo and in vitro; the authors also focus on the techniques used to fabricate these nanocomposites. Additionally, this review discusses recent developments in the use of nanocomposites for tissue engineering and represents a literature update, as well an expansion, of previously published articles on this topic.
keywords
IN-VITRO CHARACTERIZATION; CERAMIC COMPOSITE SCAFFOLDS; MESENCHYMAL STEM-CELLS; SOL-GEL; PHOSPHATE NANOPARTICLES; VIVO BIOCOMPATIBILITY; MECHANICAL-PROPERTIES; ANGIOGENIC PROPERTIES; DENTAL APPLICATIONS; POLY(LACTIC ACID)
subject category
Materials Science
authors
Erol-Taygun, M; Unalan, I; Idris, MIB; Mano, JF; Boccaccini, AR
our authors
João Mano
Vice Directoracknowledgements
J.F.M. acknowledges project CICECO-Aveiro Institute of Materials (POCI-01-0145-FEDER-007679 with ref. FCT UID/CTM/50011/2013), financed by national funds through the FCT/MEC and, when appropriate, co-financed by FEDER under the PT2020 Partnership Agreement. The authors thank Dr. Jemma Roberts for corrections on the text.