abstract
The fabrication of scaffolds that accurately recreate the architecture of living tissues is a major challenge in the field of tissue engineering and regenerative medicine. Core-shell microcapsules hold great potential in this regard, as they can recreate the hierarchical structure of biological systems. The independent modulation of the composition of both core and shell layers allows the design of compartmentalized platforms tailored to the recreation of specific cell niches. Emergent technologies such as superhydrophobic surfaces, microfluidics, electrospray, and layer-by-layer assembly have been successful in producing core-shell microcapsules for the encapsulation of cells and bioactive factors. This review provides an overview of available materials and techniques used in the generation of core-shell microcapsules, while also highlighting some of their potential applications in the design of innovative and effective tissue engineering and regenerative medicine strategies.
keywords
MINIATURIZED 3D CULTURE; DECELLULARIZED EXTRACELLULAR-MATRIX; CALCIUM ALGINATE MICROCAPSULES; MESENCHYMAL STEM-CELLS; COAXIAL ELECTROSPRAY; HYDROGEL MICROCAPSULES; PROTEIN DELIVERY; IN-VITRO; ENCAPSULATION; BONE
subject category
Materials Science
authors
Ladeira, BM; Custodio, CA; Mano, JF
our authors
Catarina de Almeida Custódio
Assistant Researcher
João Mano
Vice DirectorProjects
Hidrogéis de Lisados de Plaquetas para Regeneração do Miocárdio (BEAT)
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)
acknowledgements
The authors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) for project Beat (PTDC/BTM-MAT/30869/2017). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the FCT/MCTES. Catarina A. Custodio also acknowledges the FCT for the individual contract 2020.01647.CEECIND. The authors would also like to acknowledge financial support by the European Research Council (ERC) for project ATLAS (ERC-2014-ADG-669858). The work was also partially supported by the European Union (EU) Horizon 2020 for the project InterLynk, Grant agreement: H2020-NMBP-TR-IND-2020, Project ID: 953169.