Perspectives for Ag2S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality

authors	Shen, YL; Lifante, J; Ximendes, E; Santos, HDA; Ruiz, D; Juarez, BH; Gutierrez, IZ; Vera, VA; Retama, JR; Rodriguez, EM; Ortgies, DH; Jaque, D; Benayas, A; del Rosal, B
nationality	International
journal	NANOSCALE
keywords	NEAR-INFRARED FLUORESCENCE; QUANTUM DOTS; BRAIN TEMPERATURE; OPTICAL-PROPERTIES; PHOTOTHERMAL THERAPY; ELECTRONIC-STRUCTURE; AMBIENT-TEMPERATURE; WAVELENGTH RANGE; HUMAN SKIN; NANOCRYSTALS
abstract	Research on near-infrared (NIR) bioimaging has progressed very quickly in the past few years, as fluorescence imaging is reaching a credible implementation as a preclinical technique. The applications of NIR bioimaging in theranostics have contributed to its increasing impact. This has brought about the development of novel technologies and, simultaneously, of new contrast agents capable of acting as efficient NIR optical probes. Among these probes, Ag2S nanoparticles (NPs) have attracted increasing attention due to their temperature-sensitive NIR-II emission, which can be exploited for deep-tissue imaging and thermometry, and their heat delivery capabilities. This multifunctionality makes Ag2S NPs ideal candidates for theranostics. This review presents a critical analysis of the synthesis routes, properties and optical features of Ag2S NPs. We also discuss the latest and most remarkable achievements enabled by these NPs in preclinical imaging and theranostics, together with a critical assessment of their potential to face forthcoming challenges in biomedicine.
publisher	ROYAL SOC CHEMISTRY
issn	2040-3364
isbn	2040-3372
year published	2019
volume	11
issue	41
beginning page	19251
ending page	19264
digital object identifier (doi)	10.1039/c9nr05733a
web of science category	Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
subject category	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier	WOS:000498821300019