abstract
Research on near-infrared (NIR) bioimaging has progressed very quickly in the past few years, as fluorescence imaging is reaching a credible implementation as a preclinical technique. The applications of NIR bioimaging in theranostics have contributed to its increasing impact. This has brought about the development of novel technologies and, simultaneously, of new contrast agents capable of acting as efficient NIR optical probes. Among these probes, Ag2S nanoparticles (NPs) have attracted increasing attention due to their temperature-sensitive NIR-II emission, which can be exploited for deep-tissue imaging and thermometry, and their heat delivery capabilities. This multifunctionality makes Ag2S NPs ideal candidates for theranostics. This review presents a critical analysis of the synthesis routes, properties and optical features of Ag2S NPs. We also discuss the latest and most remarkable achievements enabled by these NPs in preclinical imaging and theranostics, together with a critical assessment of their potential to face forthcoming challenges in biomedicine.
keywords
NEAR-INFRARED FLUORESCENCE; QUANTUM DOTS; BRAIN TEMPERATURE; OPTICAL-PROPERTIES; PHOTOTHERMAL THERAPY; ELECTRONIC-STRUCTURE; AMBIENT-TEMPERATURE; WAVELENGTH RANGE; HUMAN SKIN; NANOCRYSTALS
subject category
Chemistry; Science & Technology - Other Topics; Materials Science; Physics
authors
Shen, YL; Lifante, J; Ximendes, E; Santos, HDA; Ruiz, D; Juarez, BH; Gutierrez, IZ; Vera, VA; Retama, JR; Rodriguez, EM; Ortgies, DH; Jaque, D; Benayas, A; del Rosal, B
our authors
Antonio Hernández Benayas
ResearcherGroups
Projects
Nanoparticles - based 2D thermal bioimaging technologies - NanoTBTech (NanoTBTech)
Thermometry and Photoacoustic-Imaging Outstanding Nanoprobes (TEMPTATION)
acknowledgements
This work was supported by the Spanish Ministry of Economy and Competitiveness under projects MAT2016-75362-C3-1-R, MAT2017-83111R, and MAT2017-85617-R, by the Instituto de Salud Carlos III (PI16/00812), by the Comunidad Autonoma de Madrid (B2017/BMD-3867RENIMCM), and co-financed by the European Structural and investment fond. Additional funding was provided by the European Commission, Horizon 2020 project NanoTBTech, the Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal project IMP18_38 (2018/0265) and also by COST action CM1403. Y. L. S. acknowledges a scholarship from the China Scholarship Council (No. 201806870023). D. H. O. is grateful to the Instituto de Salud Carlos III for a Sara Borrell scholarship (No. CD17/00210). D. R thanks IMDEA Nanoscience for his contract. A. B. thanks the European Commission as this project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska Curie grant agreement no. 709270 TEMPTATION.