A polynuclear Cu(ii) complex for real time monitoring of mitochondrial cytochromeCrelease during cellular apoptosis

authors	Khanra, S; Ta, S; Paladhi, A; Ghosh, M; Ghosh, S; Hira, SK; Manna, PP; Brandao, P; Felix, V; Das, D
nationality	International
journal	CHEMICAL COMMUNICATIONS
abstract	A new amide-imine conjugate, 2-hydroxybenzoic acid-(2-hydroxybenzylidene)-hydrazide (L-1), is employed to prepare a single crystal X-ray structurally characterized poly-nuclear Cu(ii) complex (M1). M1 selectively and spatially interacts with cytochromeC(CytC) to allow fluorescence imaging of intracellular translocation events in living cells. Thus, direct visualization of a CytCtranslocation event during an apoptotic process is achieved for the first time. The binding constant and LOD are 7.52 x 10(4)M(-1)and 34.0 nM, respectively.
publisher	ROYAL SOC CHEMISTRY
issn	1359-7345
isbn	1364-548X
year published	2020
volume	56
issue	48
beginning page	6563
ending page	6566
digital object identifier (doi)	10.1039/d0cc01606c
web of science category	Chemistry, Multidisciplinary
subject category	Chemistry
unique article identifier	WOS:000544281500019