authors |
Debasu, ML; Oliveira, H; Rocha, J; Carlos, LD |
nationality |
International |
journal |
JOURNAL OF RARE EARTHS |
author keywords |
Gd2O3; Nd3+-doped nanoparticles; Luminescent nanothermometry; Thermal sensitivity; Cytotoxicity of nanoparticles; Rare earths |
keywords |
UP-CONVERSION; THERMAL SENSITIVITY; NANOPARTICLES; NANOCRYSTALS; THERMOMETRY; SIZE |
abstract |
Non-contact, self-referenced and near-infrared luminescent nanothermometers have been recognized as emerging tools in the fields of nanomedicine and nanotechnology due to their great capability of precise temperature readout at the nanoscale and real-time deep-tissue imaging. However, the development of multifunctional and biocompatible luminescent nanothermometers operating within the optically transparent biological windows with high thermal sensitivity (>2.0%/K) remains challenging. Here, we present (Gd0.98Nd0.02)(2)O-3 nanothermometers operated effectively within the first and second biological windows upon continuous-wave laser diode excitation at 808 nm. Ratiometric thermometric parameters are defined by the relative changes in the emission intensities originating from the two Stark components of the F-4(3/2) level (R-2 and R-1) to the I-4(9/2) (900-1000 nm), I-4(11/2) (1035-1155 nm) and I-4(13/2) (1300-1450 nm) multiplets. The thermometric parameters are evaluated for colloidal samples in a cell culture medium and powder samples, and the highest thermal sensitivity (2.18%/K at 298 K) is attained for the former in the first biological window (both the excitation and emission in the 800-965 nm range). The repeatability and temperature uncertainty are 99% and 1.2 K, respectively. The nanothermometers are biocompatible with human MNT-1 melanoma and HaCaT cells for 24 h of exposure and nanoparticle concentration up to 0.400 mg/mL, showing their potential for applications in nanomedicine, e.g., intracellular imaging and temperature mapping. (C) 2020 Chinese Society of Rare Earths. Published by Elsevier B.V. All rights reserved. |
publisher |
ELSEVIER |
issn |
1002-0721 |
year published |
2020 |
volume |
38 |
issue |
5 |
beginning page |
483 |
ending page |
491 |
digital object identifier (doi) |
10.1016/j.jre.2019.12.011 |
web of science category |
Chemistry, Applied |
subject category |
Chemistry |
unique article identifier |
WOS:000534541200005
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
3.104 |
5 year journal impact factor |
2.838 |
category normalized journal impact factor percentile |
72.535 |
dimensions (citation analysis):
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altmetrics (social interaction):
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