Nanostructured functionalized magnetic platforms for the sustained delivery of cisplatin: Synthesis, characterization and in vitro cytotoxicity evaluation

authors	BJM Leite Ferreira, F Martel, C Silva, TM Santos, AL Daniel-da-Silva
nationality	International
journal	Journal of Inorganic Biochemistry
abstract	Cisplatin has demonstrated extraordinary anticancer activity against a variety of solid tumors. However, its clinical efficacy is contrasted by its toxicity profile. Having in mind the need to reduce the toxicity, promote a sustained release and enhance the body-circulation time of cisplatin, herein novel nanocarriers consisting of core–shell silica-coated iron oxide nanoparticles functionalized with dicarboxylic acid groups were prepared and characterized. Cisplatin was conjugated with the functionalized nanoparticles by surface tethering. Controlled release of cisplatin was observed without burst effect and in a sustained profile for up to 3 days. In vitro studies showed cytotoxic and antiproliferative effects of the cisplatin nanoconjugates against a human pancreatic cancer cell line. Importantly, when compared with free cisplatin, nanoconjugates exhibited lower cytotoxic effects regarding nonmalignant human duct pancreatic cells.
year published	2020
volume	213
beginning page	111258
digital object identifier (doi)	https://doi.org/10.1016/j.jinorgbio.2020.111258
unique article identifier	https://www.sciencedirect.com/science/article/pii/S0162013420302865