Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
authors Dias, AS; Helguero, L; Almeida, CR; Duarte, IF
nationality International
journal MOLECULES
author keywords tumor microenvironment; stromal cells; metabolism; metabolic modulation; natural compounds; phytochemicals; cancer
keywords CANCER STEM-CELLS; 3T3-L1 ADIPOCYTES; GLUTAMINE UPTAKE; DENDRITIC CELLS; MACROPHAGES; CURCUMIN; INHIBITION; ACID; LACTATE; (-)-EPIGALLOCATECHIN-3-GALLATE
abstract The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to '(re)-educate' TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression.
publisher MDPI
isbn 1420-3049
year published 2021
volume 26
issue 12
digital object identifier (doi) 10.3390/molecules26123494
web of science category 18
subject category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
unique article identifier WOS:000666525000001
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journal analysis (jcr 2019):
journal impact factor 3.267
5 year journal impact factor 3.589
category normalized journal impact factor percentile 56.714
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