Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
authors Bharmoria, P; Bisht, M; Gomes, MC; Martins, M; Neves, MC; Mano, JF; Bdikin, I; Coutinho, JAP; Ventura, SPM
nationality International
journal SCIENTIFIC REPORTS
keywords ANTIOXIDANT ACTIVITY; MICROEMULSIONS; NANOPARTICLES
abstract The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept.
publisher NATURE RESEARCH
issn 2045-2322
year published 2021
volume 11
issue 1
digital object identifier (doi) 10.1038/s41598-021-88482-3
web of science category 12
subject category Multidisciplinary Sciences
unique article identifier WOS:000647136200013
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journal analysis (jcr 2019):
journal impact factor 3.998
5 year journal impact factor 4.576
category normalized journal impact factor percentile 76.761
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