Hydrosulfide (HS-) Recognition and Sensing in Water by Halogen Bonding Hosts
authors Mitchell, EJ; Beecroft, AJ; Martin, J; Thompson, S; Marques, I; Felix, V; Beer, PD
nationality International
journal ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
author keywords coumarin; fluorescent sensing; halogen bonding; hydrosulfide; anion recognition
keywords HYDROGEN-SULFIDE; ANION RECOGNITION; SUPRAMOLECULAR CHEMISTRY; ELECTRON-DENSITY; H2S
abstract Hydrogen sulfide (H2S) plays a crucial signalling role in a variety of physiological systems, existing as the hydrosulfide anion (HS-) at physiological pH. Combining the potency of halogen bonding (XB) for anion recognition in water with coumarin fluorophore incorporation in acyclic host structural design, the first XB receptors to bind and, more importantly, sense the hydrosulfide anion in pure water in a reversible chemosensing fashion are demonstrated. The XB receptors exhibit characteristic selective quenching of fluorescence upon binding to HS-. Computational DFT and molecular dynamics simulations in water corroborate the experimental anion binding observations, revealing the mode and nature of HS- recognition by the XB receptors.
publisher WILEY-V C H VERLAG GMBH
issn 1433-7851
isbn 1521-3773
year published 2021
volume 60
issue 45
beginning page 24048
ending page 24053
digital object identifier (doi) 10.1002/anie.202110442
web of science category 6
subject category Chemistry, Multidisciplinary
unique article identifier WOS:000710630000020
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 12.959
5 year journal impact factor 12.659
category normalized journal impact factor percentile 91.808
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg