Storage and delivery of H2S by microporous and mesoporous materials


Hydrogen sulphide has therapeutic functions but because it is a gas its delivery as a drug poses specific difficulties. Porous materials have been emerging as serious candidates for the storage and release of small gas molecules with therapeutic effects. In this work, we study microporous (A, and Y zeolites; ETS-4 and ETS-10 titanosilicates) and mesoporous (SBA-15 with and without surface amines functionalization) materials. The experimental determination of the H2S amounts released from the porous materials in liquid phase was challenging. For this, two methodologies were used, the detection through the methylene blue reaction and by a selective electrode. In the end, considering the storage amounts, the release profile and the cytotoxicity, 4A zeolite and ETS-10 titanosilicate showed the best properties.



subject category

Chemistry, Applied; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary


Fernandes, AC; Pinto, R; Carvalho, S; Mafra, L; Rocha, J; Pinto, M; Antunes, F; Pires, J

our authors


This research was financed by Fundacao para a Ciencia e a Tecnologia (FCT) through projects PTDC/MEDQUI/28721/2017 and developed in the scope of the projects UIDB/00100/2020 (CQE) , UIDB/04028/2020, UIDP/04028/2020 (CERENA) , FCT UID/CTM/50011/2019) (CICECO) , financed by Portuguese funds through the FCT/MEC and when applicable cofinanced by FEDER under the PT2020 Partnership Agreement. RVP acknowledges for the grant 16/BAD/2017 provided by Colegio de Quimica. ACF acknowledges for the post doc grant SFRH/BPD/115953/2016.

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