New and Efficient Bioactive Glass Compositions for Controlling Endodontic Pathogens

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abstract

Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol-gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

keywords

CALCIUM HYDROXIDE; ANTIBACTERIAL EFFICIENCY; MEDICAMENTS; S53P4

subject category

Chemistry; Science & Technology - Other Topics; Materials Science; Physics

authors

Correia, BL; Gomes, ATPC; Noites, R; Ferreira, JMF; Duarte, AS

our authors

foto José Maria da Fonte Ferreira

José Maria da Fonte Ferreira

Retired Professor

Groups

G5 - Biomimetic, Biological and Living Materials

Projects

CICECO - Aveiro Institute of Materials (UID/CTM/50011/2019)

acknowledgements

This work was developed within the scope of the projects of the CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019 and of the CIIS-UCP, Viseu, FCT Ref. UIDB/04279/2020. Thanks are also due to FCT and UCP for the CEEC institutional financing of Ana T.P.C. Gomes (CEECINST/00137/2018/CP1520/CT0022) and Ana Sofia Duarte (CEECINST/00137/2018/CP1520/CT0013).

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Publication Details

type
Journal Article
year
2022
journal
NANOMATERIALS
volume
12
article number
1577
publisher
MDPI
issue
9
digital object identifier
10.3390/nano12091577
web of science article identifier
WOS:000794786300001

Journal Metrics (JCR 2019)

Journal Impact Factor
4.324
Journal Impact Factor (5 yrs)
4.514
category normalized journal percentile
65.762

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