abstract
Over the past few decades, natural-origin polysaccharides have received increasing attention across different fields of application, including biomedicine and biotechnology, because of their specific physicochemical and biological properties that have afforded the fabrication of a plethora of multifunctional devices for healthcare applications. More recently, marine raw materials from fisheries and aquaculture have emerged as a highly sustainable approach to convert marine biomass into added-value polysaccharides for human benefit. Nowadays, significant efforts have been made to combine such circular bio-based approach with cost-effective and environmentally-friendly technologies that enable the isolation of marine-origin polysaccharides up to the final construction of a biomedical device, thus developing an entirely sustainable pipeline. In this regard, the present review intends to provide an up-to-date outlook on the current green extraction methodologies of marine-origin polysaccharides and their molecular engineering toolbox for designing a multitude of biomaterial platforms for healthcare. Furthermore, we discuss how to foster circular bio-based approaches to pursue the further development of added-value biomedical devices, while preserving the marine ecosystem.
authors
Margarida M. A. Sacramento, João Borges, Fernando J. S. Correia, Ricardo Calado, João M. M. Rodrigues, Sónia G. Patrício, João F. Mano
our authors
João M. M. Rodrigues
Assistant ResearcherProjects
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
BlueGlue: Bioinspired medical adhesives from marine macroalgae derived biopolymers (BLUEGLUE)
acknowledgements
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020), financed by national funds (OE) through the FCT/MEC (PIDDAC). This work was also financed by Fundo Azul Call–N.° 5/2017 and Direção-Geral de Política do Mar (DGMP) do Ministério do Mar Português within the scope of project BLUEGLUE (FA_05_2017_031), as well as by OE through FCT in the scope of the following projects: “MIMETIc” (PTDC/BTM-MAT/31210/2017) and “COP2P” (PTDC/QUI-QOR/30771/2017), both also supported Programa Operacional Competitividade e Internacionalização (POCI-01-0145-FEDER-031210 and POCI-01-0145-FEDER-030771), respectively, in its FEDER component; and “SUPRASORT” (PTDC/QUI-OUT/30658/2017), also supported by Programa Operacional Regional do Centro–Centro 2020 (CENTRO-01-0145-FEDER-030658) in the component FEDER.