Green approaches for extraction, chemical modification and processing of marine polysaccharides for biomedical applications


Over the past few decades, natural-origin polysaccharides have received increasing attention across different fields of application, including biomedicine and biotechnology, because of their specific physicochemical and biological properties that have afforded the fabrication of a plethora of multifunctional devices for healthcare applications. More recently, marine raw materials from fisheries and aquaculture have emerged as a highly sustainable approach to convert marine biomass into added-value polysaccharides for human benefit. Nowadays, significant efforts have been made to combine such circular bio-based approach with cost-effective and environmentally-friendly technologies that enable the isolation of marine-origin polysaccharides up to the final construction of a biomedical device, thus developing an entirely sustainable pipeline. In this regard, the present review intends to provide an up-to-date outlook on the current green extraction methodologies of marine-origin polysaccharides and their molecular engineering toolbox for designing a multitude of biomaterial platforms for healthcare. Furthermore, we discuss how to foster circular bio-based approaches to pursue the further development of added-value biomedical devices, while preserving the marine ecosystem.


Margarida M. A. Sacramento, João Borges, Fernando J. S. Correia, Ricardo Calado, João M. M. Rodrigues, Sónia G. Patrício, João F. Mano

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This work was developed within the scope of the project CICECO-Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020), financed by national funds (OE) through the FCT/MEC (PIDDAC). This work was also financed by Fundo Azul Call–N.° 5/2017 and Direção-Geral de Política do Mar (DGMP) do Ministério do Mar Português within the scope of project BLUEGLUE (FA_05_2017_031), as well as by OE through FCT in the scope of the following projects: “MIMETIc” (PTDC/BTM-MAT/31210/2017) and “COP2P” (PTDC/QUI-QOR/30771/2017), both also supported Programa Operacional Competitividade e Internacionalização (POCI-01-0145-FEDER-031210 and POCI-01-0145-FEDER-030771), respectively, in its FEDER component; and “SUPRASORT” (PTDC/QUI-OUT/30658/2017), also supported by Programa Operacional Regional do Centro–Centro 2020 (CENTRO-01-0145-FEDER-030658) in the component FEDER.

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