resumo
Microfluidics has become an important tool to engineer microenvironments with high precision, comprising devices and methods for controlling and manipulating fluids at the submillimeter scale. A specific branch of microfluidics comprises open fluidic systems, which is mainly characterized by displaying a higher air/liquid interface when compared with traditional closed-channel setups. The use of open channel systems has enabled the design of singular architectures in devices that are simple to fabricate and to clean. Enhanced functionality and accessibility for liquid handling are additional advantages inputted to technologies based on open fluidics. While benchmarked against closed fluidics approaches, the use of directly accessible channels decreases the risk of clogging and bubble-driven flow perturbation. In this review, we discuss the advantages of open fluidics systems when compared to their closed fluidics counterparts. Platforms are analyzed in two separated groups based on different confinement principles: wall-based physical confinement and wettability-contrast confinement. The physical confinement group comprises both open and traditional microfluidics; examples based on open channels with rectangular and triangular cross-section, suspended microfluidics, and the use of narrow edge of a solid surface for fluid confinement are addressed. The second group covers (super)hydrophilic/(super) hydrophobic patterned surfaces, and examples based on polymer-, textile- and paper-based microfluidic devices are explored. The technologies described in this review are critically discussed concerning devices' performance and versatility, manufacturing techniques and fluid transport/manipulation methods. A gather-up of recent biomedical applications of open fluidics devices is also presented.
palavras-chave
SUPERHYDROPHOBIC-PATTERNED SURFACE; SPONTANEOUS CAPILLARY-FLOW; ON-A-CHIP; RECENT PROGRESS; DRIVEN FLOW; MICROFLUIDIC TRANSPORT; BIOINSPIRED SURFACES; STRUCTURED SURFACES; ANALYTICAL DEVICES; DROPLET-ARRAY
categoria
Materials Science
autores
Oliveira, NM; Vilabril, S; Oliveira, MB; Reis, RL; Mano, JF
nossos autores
João Mano
Vice-Diretor
Mariana Braga de Oliveira
Investigador Auxiliar
Sara Vilabril Ramos
Bolseiro de investigaçãoagradecimentos
The authors acknowledge funding from the European Research Council grant agreement ERC-2012-ADG 20120216-321266 for project ComplexiTE and ERC-2014-ADG-669858 for project ATLAS. N. M. Oliveira acknowledges the financial support from Portuguese Foundation for Science and Technology FCT (Grant SFRH/BD/73172/2010), from the financial program POPH/FSE from QREN. The work was developed within the scope of the project CICECO Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013). Sara Vilabril acknowledges the financial support from national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement.