Separation of natural compounds using eutectic solvent-based biphasic systems and centrifugal partition chromatography

  1. Home
  2. Research
  3. Publications

abstract

A study on the formation of ternary biphasic systems composed of heptane, 1-butanol or ethyl acetate and type III or type V deep eutectic solvents based on levulinic acid and choline chloride or thymol was carried. Binodal curves and densities and phase compositions of phases in equilibrium for seven systems are reported. The partition coefficients of six natural compounds, namely quercetin, apigenin, coumarin, beta-ionone, retinol, and alpha-tocopherol, in these systems were measured. Results show that the influence of choline chloride on the partition coefficients is more significant in systems with 1-butanol or ethyl acetate than previously reported for ethanol, and that the separation of natural compounds is worst when using DES containing thymol instead of choline chloride. Based on these partition coefficients, one system composed of heptane, 1-butanol and the DES choline chloride:levulinic acid at molar ratio 1:3 was selected to be applied in centrifugal partition chromatography, and the results obtained confirmed that it allows a good separation of apigenin, coumarin, beta-ionone and alpha-tocopherol.(c) 2023 Elsevier B.V. All rights reserved.

keywords

CHOLINE CHLORIDE; COUNTER-CURRENT; ACID; COEFFICIENT; MIXTURES; MODEL; CO2

subject category

Biochemistry & Molecular Biology; Chemistry

authors

Chagnoleau, JB; Ryan, IL; Khedher, R; AP Coutinho, J; Michel, T; Fernandez, X; Papaiconomou, N

our authors

foto João Manuel Costa Araújo Pereira Coutinho

João Manuel Costa Araújo Pereira Coutinho

Director

Groups

G4 - Renewable Materials and Circular Economy

Projects

CICECO - Aveiro Institute of Materials (UIDB/50011/2020)

CICECO - Aveiro Institute of Materials (UIDP/50011/2020)

Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)

Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)

acknowledgements

This work was developed within the scope of the project CICECO-Aveiro Institute of Materials , UIDB/50011/2020 , UIDP/50011/2020 & LA/P/0006/2020 , financed by national funds through the FCT/MCTES (PIDDAC) . J -B C. is grateful to the EUR Spectrum - Graduate school of Formal, Physical and Engineering Sciences- for his Ph.D. financing.

Share this project:

Related Publications

Publication Details

type
Journal Article
year
2023
journal
JOURNAL OF CHROMATOGRAPHY A
volume
1691
article number
463812
publisher
ELSEVIER
issn
0021-9673
digital object identifier
10.1016/j.chroma.2023.463812
web of science article identifier
WOS:000963719400001

Journal Metrics (JCR 2019)

Journal Impact Factor
4.049
Journal Impact Factor (5 yrs)
3.861
category normalized journal percentile
84.034

Citations

Social Interaction

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".


Privacy and Cookie Policy

Personal data

CICECO-Aveiro Institute of Materials respects your privacy, ensuring confidentiality of personal data you share with the institution through this way, not collecting any personal information about you without your consent, under the terms required by General Data Protection Regulations (RGPD).

The data collected in forms are intended exclusively for processing user requests and will not be used for any other purpose, always safeguarding their confidentiality, under the terms of the protection conferred by the aforementioned regulation.

The collection and processing of data is the responsibility of CICECO and its storage is properly protected, only authorized CICECO employees can access the information within the scope of their functions, always being clear in the respective collection forms the purposes for which they are intended. The remaining issues to be considered in this matter will be handled by the University of Aveiro in accordance with the regime established by the GDPR.

Cookies policy

Cookies are small files with alphanumeric information that are stored on your computer's hard drive by your browser and are intended to improve the user experience and enhance website navigation.

Collection and use of technical information

The cookies used on CICECO are anonymous, and no information about our users that allows their personal identification is stored in them.

The technical information recorded consists of:

  • iP (Internet Protocol) address of the visitor;
  • the type of internet browser used by the website visitor and the respective operating system used;
  • the date and time of the consultation;
  • the pages visited on the site and the documents downloaded
  • The technical information collected is used for statistical purposes only.

Cookies used

Session cookies

These cookies are used to record user preferences, such as the language in which websites are displayed or to maintain authenticated user sessions, and are automatically deleted when the browser is closed.

Persistent cookies

These cookies store information that is needed between sessions. For example, a persistent cookie is set to record that you have been made aware of the cookie policy so that the message regarding this policy is not shown again the next time you visit the website. This cookie remains on the computer until it reaches its expiry date or is deleted by the user.

Data protection

The present privacy policy covers the Information System of the University of Aveiro (SIUA), governed by the General Data Protection Regulations (RGPD) Regulation (EU) No. 2016/679, of April 27th, 2016.

Data Protection Officer

The University of Aveiro has a Data Protection Officer (DPO), who ensures compliance of the processing of personal data with the legislation in force, and is available through the following email address epd@ua.pt.

Close