Biocellulose Membranes as Supports for Dermal Release of Lidocaine

  1. Home
  2. Research
  3. Publications

abstract

Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.

keywords

MOLECULARLY IMPRINTED POLYMER; CONTROLLED DRUG-DELIVERY; BACTERIAL CELLULOSE; TRANSDERMAL DELIVERY; RACEMIC PROPRANOLOL; MICROBIAL CELLULOSE; COMPOSITE MEMBRANE; BIOMATERIALS; ABSORPTION; SYSTEM

subject category

Biochemistry & Molecular Biology; Chemistry; Polymer Science

authors

Trovatti, E; Silva, NHCS; Duarte, IF; Rosado, CF; Almeida, IF; Costa, P; Freire, CSR; Silvestre, AJD; Neto, CP

our authors

foto Armando Jorge Domingues Silvestre

Armando Jorge Domingues Silvestre

Full professor
foto Carlos Pascoal Neto

Carlos Pascoal Neto

Raiz Director
foto Carmen Sofia da Rocha Freire Barros

Carmen Sofia da Rocha Freire Barros

Coordinating Researcher
foto Iola Melissa Fernandes Duarte

Iola Melissa Fernandes Duarte

Principal Researcher
foto Nuno Helder da Cruz Simões Silva

Nuno Helder da Cruz Simões Silva

Researcher

Groups

G4 - Renewable Materials and Circular Economy
G5 - Biomimetic, Biological and Living Materials

acknowledgements

E.T. is grateful to FCT (Fundacao para a Ciencia e Tecnologia) and POPH/FSE for Grant SFRH/BPD/63250/2009.

Share this project:

Related Publications

Publication Details

type
Journal Article
year
2011
journal
BIOMACROMOLECULES
volume
12
publisher
AMER CHEMICAL SOC
issn
1525-7797
issue
11
digital object identifier
10.1021/bm201303r
web of science article identifier
WOS:000296830600039

Journal Metrics (JCR 2019)

Journal Impact Factor
6.092
Journal Impact Factor (5 yrs)
5.775
category normalized journal percentile
92.195

Citations

Social Interaction

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".


Privacy and Cookie Policy

Personal data

CICECO-Aveiro Institute of Materials respects your privacy, ensuring confidentiality of personal data you share with the institution through this way, not collecting any personal information about you without your consent, under the terms required by General Data Protection Regulations (RGPD).

The data collected in forms are intended exclusively for processing user requests and will not be used for any other purpose, always safeguarding their confidentiality, under the terms of the protection conferred by the aforementioned regulation.

The collection and processing of data is the responsibility of CICECO and its storage is properly protected, only authorized CICECO employees can access the information within the scope of their functions, always being clear in the respective collection forms the purposes for which they are intended. The remaining issues to be considered in this matter will be handled by the University of Aveiro in accordance with the regime established by the GDPR.

Cookies policy

Cookies are small files with alphanumeric information that are stored on your computer's hard drive by your browser and are intended to improve the user experience and enhance website navigation.

Collection and use of technical information

The cookies used on CICECO are anonymous, and no information about our users that allows their personal identification is stored in them.

The technical information recorded consists of:

  • iP (Internet Protocol) address of the visitor;
  • the type of internet browser used by the website visitor and the respective operating system used;
  • the date and time of the consultation;
  • the pages visited on the site and the documents downloaded
  • The technical information collected is used for statistical purposes only.

Cookies used

Session cookies

These cookies are used to record user preferences, such as the language in which websites are displayed or to maintain authenticated user sessions, and are automatically deleted when the browser is closed.

Persistent cookies

These cookies store information that is needed between sessions. For example, a persistent cookie is set to record that you have been made aware of the cookie policy so that the message regarding this policy is not shown again the next time you visit the website. This cookie remains on the computer until it reaches its expiry date or is deleted by the user.

Data protection

The present privacy policy covers the Information System of the University of Aveiro (SIUA), governed by the General Data Protection Regulations (RGPD) Regulation (EU) No. 2016/679, of April 27th, 2016.

Data Protection Officer

The University of Aveiro has a Data Protection Officer (DPO), who ensures compliance of the processing of personal data with the legislation in force, and is available through the following email address epd@ua.pt.

Close